| An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. | |
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MedLine Citation:
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PMID: 11169821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although proton magnetic resonance spectroscopic imaging (1H-MRSI) has been shown to be effective for localizing tumor in patients with gliomas, it is not a routinely used clinical tool. This is due, in part, to the lack of a standardized, objective method for analyzing spectra. We present an automated technique for a) selecting a population of voxels from each patient that have the spectral features of normal brain regions, and b) using the selected voxels as internal controls for quantifying the probability of abnormality at each voxel location. The technique was demonstrated on a phantom, 14 normal volunteers, and 30 patients with histologically proven tumor. In addition, we demonstrated the usefulness of the method for monitoring patients in serial studies from two glioma patients with progressive disease. |
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Authors:
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T R McKnight; S M Noworolski; D B Vigneron; S J Nelson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 13 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-06-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 167-77 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of California, San Francisco, California 94143, USA. mcknight@mrsc.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives, metabolism Brain / pathology Brain Neoplasms / diagnosis*, pathology Choline / metabolism Female Glioma / diagnosis*, pathology Humans Imaging, Three-Dimensional* Magnetic Resonance Imaging Magnetic Resonance Spectroscopy* Male Models, Statistical Phantoms, Imaging |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA799719/CA/NCI NIH HHS; T32 CA66527-01A1/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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