Document Detail

An automated front-end monitor for anthrax surveillance systems based on the rapid detection of airborne endospores.
MedLine Citation:
PMID:  17514759     Owner:  NLM     Status:  MEDLINE    
A fully automated anthrax smoke detector (ASD) has been developed and tested. The ASD is intended to serve as a cost effective front-end monitor for anthrax surveillance systems. The principle of operation is based on measuring airborne endospore concentrations, where a sharp concentration increase signals an anthrax attack. The ASD features an air sampler, a thermal lysis unit, a syringe pump, a time-gated spectrometer, and endospore detection chemistry comprised of dipicolinic acid (DPA)-triggered terbium ion (Tb(3+)) luminescence. Anthrax attacks were simulated using aerosolized Bacillus atrophaeus spores in fumed silica, and corresponding Tb-DPA intensities were monitored as a function of time and correlated to the number of airborne endospores collected. A concentration dependence of 10(2)-10(6) spores/mg of fumed silica yielded a dynamic range of 4 orders of magnitude and a limit of detection of 16 spores/L when 250 L of air were sampled. Simulated attacks were detected in less than 15 min.
Pun To Yung; Elizabeth D Lester; Greg Bearman; Adrian Ponce
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biotechnology and bioengineering     Volume:  98     ISSN:  0006-3592     ISO Abbreviation:  Biotechnol. Bioeng.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502021     Medline TA:  Biotechnol Bioeng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  864-71     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley Periodicals, Inc.
California Institute of Technology, Pasadena, California 91125, USA.
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MeSH Terms
Air Pollutants / analysis*
Bacillus anthracis / isolation & purification*
Colony Count, Microbial / instrumentation*,  methods
Environmental Monitoring / instrumentation*,  methods
Equipment Design
Reproducibility of Results
Robotics / instrumentation*,  methods
Sensitivity and Specificity
Spores, Bacterial / isolation & purification*
Reg. No./Substance:
0/Air Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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