| An automated front-end monitor for anthrax surveillance systems based on the rapid detection of airborne endospores. | |
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MedLine Citation:
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PMID: 17514759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fully automated anthrax smoke detector (ASD) has been developed and tested. The ASD is intended to serve as a cost effective front-end monitor for anthrax surveillance systems. The principle of operation is based on measuring airborne endospore concentrations, where a sharp concentration increase signals an anthrax attack. The ASD features an air sampler, a thermal lysis unit, a syringe pump, a time-gated spectrometer, and endospore detection chemistry comprised of dipicolinic acid (DPA)-triggered terbium ion (Tb(3+)) luminescence. Anthrax attacks were simulated using aerosolized Bacillus atrophaeus spores in fumed silica, and corresponding Tb-DPA intensities were monitored as a function of time and correlated to the number of airborne endospores collected. A concentration dependence of 10(2)-10(6) spores/mg of fumed silica yielded a dynamic range of 4 orders of magnitude and a limit of detection of 16 spores/L when 250 L of air were sampled. Simulated attacks were detected in less than 15 min. |
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Authors:
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Pun To Yung; Elizabeth D Lester; Greg Bearman; Adrian Ponce |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 98 ISSN: 0006-3592 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 864-71 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley Periodicals, Inc. |
Affiliation:
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California Institute of Technology, Pasadena, California 91125, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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analysis* Bacillus anthracis / isolation & purification* Colony Count, Microbial / instrumentation*, methods Environmental Monitoring / instrumentation*, methods Equipment Design Reproducibility of Results Robotics / instrumentation*, methods Sensitivity and Specificity Spores, Bacterial / isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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