Document Detail


The autoimmunity in Graves's disease.
MedLine Citation:
PMID:  23276963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Graves' disease (GD) is a systemic autoimmune syndrome manifesting complications in thyroid and orbital connective tissues. The thyroid gland plays a major role in the human body by producing the hormones necessary for appropriate energy levels and an active life. At the same time, the thyroid is highly vulnerable to autoimmune thyroid diseases. GD arises due to the complex interplay of genetic, environmental and endogenous factors, and the specific combination is required to initiate thyroid autoimmunity. Earlier studies have demonstrated the autoimmune response plays a dominant role in the development of GD. This review summarizes the inflammatory events which occur during the development of GD, such as Th17/Treg cell infiltration, Th1/Th2 cytokine and chemokine production, and the subtypes of immunogloblins (IgGs) generated.
Authors:
Hong Li; Tao Wang
Related Documents :
12402993 - Biointerventional cardiology: the future interface of interventional cardiovascular med...
10695683 - Blood levels of homocysteine and increased risks of cardiovascular disease: causal or c...
16958123 - Multiple system atrophy is distinguished from idiopathic parkinson's disease by the arg...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  782-7     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. shanhongli2012@yeah.net
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity / immunology*
Graves Disease / immunology*
Graves Ophthalmopathy / immunology*
Humans
Immunoglobulin G / biosynthesis
T-Lymphocytes, Regulatory / immunology
Th1-Th2 Balance
Th17 Cells / immunology
Thyroid Gland / immunology
Chemical
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of mast cells in gynecological neoplasms.
Next Document:  The miRNAs in the pathgenesis of osteosarcoma.