Document Detail

An augmented escape of beta-endorphins to suppression by dexamethasone in severely depressed patients.
MedLine Citation:
PMID:  2139059     Owner:  NLM     Status:  MEDLINE    
Baseline beta-endorphin and cortisol levels and their responses to 1 mg dexamethasone were measured in 11 healthy controls and in 35 depressed patients, categorized according to the DSM-III. Dexamethasone significantly suppressed beta-endorphin levels. Depressed patients with melancholia/psychotic features exhibited significantly increased post-dexamethasone beta-endorphin levels compared with healthy controls, minor and simple major depressives; the baseline beta-endorphin levels did not differ between those study samples. Post-dexamethasone beta-endorphin and cortisol values were found to be significantly and positively correlated. Accordingly, cortisol non-suppressors showed significantly higher post-dexamethasone beta-endorphin levels. Post-dexamethasone beta-endorphin may be the most sensitive and specific reflection of the disorder in negative feedback exerted by dexamethasone in depression.
M Maes; M P Jacobs; E Suy; C Leclercq; F Christiaens; J Raus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of affective disorders     Volume:  18     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-21     Completed Date:  1990-05-21     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Psychiatric Centre St. Jozef, Munsterbilzen, Belgium.
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MeSH Terms
Depressive Disorder / blood,  diagnosis*,  psychology
Dexamethasone / diagnostic use*
Hydrocortisone / blood
Middle Aged
Prospective Studies
Psychiatric Status Rating Scales
beta-Endorphin / blood*
Reg. No./Substance:
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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