| An audit of nifedipine in a hypertension clinic. | |
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MedLine Citation:
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PMID: 3711359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The results of treating 235 hypertensive patients who had been prescribed nifedipine in a hypertension clinic were examined for factors affecting blood pressure response and the frequency of side-effects. Pretreatment systolic and diastolic blood pressure correlated significantly with the decrease in blood pressure but this effect was lost following statistical correction. No relation was found between response and age or race nor did any biochemical or haematological parameter predict the antihypertensive effect. Fifty-nine (25%) patients complained of side-effects which were dose related; the drug had to be discontinued in 30 patients (13%) but the remaining 29 continued at the same or reduced dosage. Small, but statistically significant, elevations were seen in serum albumin, alkaline phosphatase and bilirubin as well as a rise in average blood glucose levels. Although side-effects are fairly common nifedipine is an effective antihypertensive drug when given alone or in combination with other therapies. |
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Authors:
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J S Gill; A V Zezulka; M Beevers; D G Beevers |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical and hospital pharmacy Volume: 11 ISSN: 0143-3180 ISO Abbreviation: J Clin Hosp Pharm Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-07-18 Completed Date: 1986-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006505 Medline TA: J Clin Hosp Pharm Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 107-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Blood Pressure / drug effects Dose-Response Relationship, Drug Drug Therapy, Combination Female Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Nifedipine / adverse effects, therapeutic use* Sex Factors |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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