Document Detail


An audit of nifedipine in a hypertension clinic.
MedLine Citation:
PMID:  3711359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of treating 235 hypertensive patients who had been prescribed nifedipine in a hypertension clinic were examined for factors affecting blood pressure response and the frequency of side-effects. Pretreatment systolic and diastolic blood pressure correlated significantly with the decrease in blood pressure but this effect was lost following statistical correction. No relation was found between response and age or race nor did any biochemical or haematological parameter predict the antihypertensive effect. Fifty-nine (25%) patients complained of side-effects which were dose related; the drug had to be discontinued in 30 patients (13%) but the remaining 29 continued at the same or reduced dosage. Small, but statistically significant, elevations were seen in serum albumin, alkaline phosphatase and bilirubin as well as a rise in average blood glucose levels. Although side-effects are fairly common nifedipine is an effective antihypertensive drug when given alone or in combination with other therapies.
Authors:
J S Gill; A V Zezulka; M Beevers; D G Beevers
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical and hospital pharmacy     Volume:  11     ISSN:  0143-3180     ISO Abbreviation:  J Clin Hosp Pharm     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-07-18     Completed Date:  1986-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006505     Medline TA:  J Clin Hosp Pharm     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Nifedipine / adverse effects,  therapeutic use*
Sex Factors
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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