Document Detail

The atypical antipsychotic sertindole: a case series.
MedLine Citation:
PMID:  9378698     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Psychotic disorders are often difficult to treat with traditional neuroleptics. Sertindole is a new atypical neuroleptic with a broader CNS receptor profile. METHOD: Ten patients diagnosed with either schizophrenia or schizoaffective disorder were treated with sertindole for 18 months and observed for changes in Clinical Global Impression scale scores. RESULTS: Nine patients experienced a reduction of symptoms after 12 months of treatment. Eight patients completed 18 months of treatment, all exhibiting overall improvement. Despite side effects of tiredness, weight gain, headache, nausea, and decreased ejaculatory volume, sertindole was generally well tolerated. CONCLUSION: Sertindole appears to be a useful treatment in psychotic disorders. It may present an advantage over traditional neuroleptics in the form of fewer extrapyramidal symptoms and improvement of negative symptoms.
A M Lee; J L Knoll; T Suppes
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Publication Detail:
Type:  Case Reports; Clinical Trial; Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  58     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-07     Completed Date:  1997-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-6; quiz 417-8     Citation Subset:  IM    
Mental Health Connections Research, Dallas, Texas, USA.
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MeSH Terms
Antipsychotic Agents / adverse effects,  pharmacology,  therapeutic use*
Delusions / drug therapy*,  psychology
Drug Administration Schedule
Headache / chemically induced
Imidazoles / adverse effects,  pharmacology,  therapeutic use*
Indoles / adverse effects,  pharmacology,  therapeutic use*
Middle Aged
Nausea / chemically induced
Psychiatric Status Rating Scales
Psychotic Disorders / drug therapy*,  psychology
Receptors, Adrenergic, alpha / drug effects
Receptors, Dopamine D2 / drug effects
Receptors, Serotonin / drug effects
Schizophrenia / drug therapy*
Schizophrenic Psychology
Treatment Outcome
Weight Gain
Reg. No./Substance:
0/Antipsychotic Agents; 0/Imidazoles; 0/Indoles; 0/Receptors, Adrenergic, alpha; 0/Receptors, Dopamine D2; 0/Receptors, Serotonin; 106516-24-9/sertindole

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