| The atypical antipsychotic sertindole: a case series. | |
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MedLine Citation:
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PMID: 9378698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Psychotic disorders are often difficult to treat with traditional neuroleptics. Sertindole is a new atypical neuroleptic with a broader CNS receptor profile. METHOD: Ten patients diagnosed with either schizophrenia or schizoaffective disorder were treated with sertindole for 18 months and observed for changes in Clinical Global Impression scale scores. RESULTS: Nine patients experienced a reduction of symptoms after 12 months of treatment. Eight patients completed 18 months of treatment, all exhibiting overall improvement. Despite side effects of tiredness, weight gain, headache, nausea, and decreased ejaculatory volume, sertindole was generally well tolerated. CONCLUSION: Sertindole appears to be a useful treatment in psychotic disorders. It may present an advantage over traditional neuroleptics in the form of fewer extrapyramidal symptoms and improvement of negative symptoms. |
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Authors:
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A M Lee; J L Knoll; T Suppes |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 58 ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-07 Completed Date: 1997-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 410-6; quiz 417-8 Citation Subset: IM |
Affiliation:
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Mental Health Connections Research, Dallas, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antipsychotic Agents / adverse effects, pharmacology, therapeutic use* Delusions / drug therapy*, psychology Drug Administration Schedule Female Headache / chemically induced Humans Imidazoles / adverse effects, pharmacology, therapeutic use* Indoles / adverse effects, pharmacology, therapeutic use* Male Middle Aged Nausea / chemically induced Psychiatric Status Rating Scales Psychotic Disorders / drug therapy*, psychology Receptors, Adrenergic, alpha / drug effects Receptors, Dopamine D2 / drug effects Receptors, Serotonin / drug effects Schizophrenia / drug therapy* Schizophrenic Psychology Treatment Outcome Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Imidazoles; 0/Indoles; 0/Receptors, Adrenergic, alpha; 0/Receptors, Dopamine D2; 0/Receptors, Serotonin; 106516-24-9/sertindole |
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