Document Detail

Is the attenuation of beta-adrenergic agonist efficacy during labor caused by elevated prostaglandin E levels?
MedLine Citation:
PMID:  9822495     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to investigate whether attenuation of beta-adrenergic agonist efficacy during labor is due to elevated prostaglandin E levels. STUDY DESIGN: beta-Receptor function (response to beta-agonist or forskolin) was tested in mononuclear leukocytes collected from women at term before or during labor. beta-Receptor function was also tested in mononuclear leukocytes of nonlaboring patients after in vitro incubation with oxytocin (1 micromol/L), prostaglandin E2 (10 micromol/L), prostaglandin F2alpha (10 micromol/L), or buffer alone. RESULTS: Mononuclear leukocytes from women in active labor exhibited a significant attenuation of beta-adrenergic receptor function as a result of reduced adenylyl cyclase activity. This effect could be induced in mononuclear leukocytes from nonlaboring women by preincubation with prostaglandin E but not oxytocin or prostaglandin F. CONCLUSIONS: Prostaglandin E induces heterologous desensitization of the beta-adrenergic receptor system in mononuclear leukocytes, comparable to that seen during labor. We speculate that during labor the elevated levels of prostaglandin E may induce similar effects on the myometrium, thereby decreasing the efficacy of beta-agonists as tocolytics.
S J Lye; P Bernstein; M Oskamp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1168-74     Citation Subset:  AIM; IM    
Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Adenylate Cyclase / metabolism
Adrenergic beta-Agonists / pharmacology*
Cyclic AMP / metabolism
Dinoprostone / pharmacology
Isoproterenol / pharmacology
Labor, Obstetric / blood,  physiology*
Monocytes / drug effects,  metabolism
Myometrium / drug effects
Oxytocics / pharmacology
Prostaglandins E / blood*
Time Factors
Tocolytic Agents / pharmacology
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Oxytocics; 0/Prostaglandins E; 0/Tocolytic Agents; 363-24-6/Dinoprostone; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol; EC Cyclase

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