| Is the attenuation of beta-adrenergic agonist efficacy during labor caused by elevated prostaglandin E levels? | |
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MedLine Citation:
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PMID: 9822495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our purpose was to investigate whether attenuation of beta-adrenergic agonist efficacy during labor is due to elevated prostaglandin E levels. STUDY DESIGN: beta-Receptor function (response to beta-agonist or forskolin) was tested in mononuclear leukocytes collected from women at term before or during labor. beta-Receptor function was also tested in mononuclear leukocytes of nonlaboring patients after in vitro incubation with oxytocin (1 micromol/L), prostaglandin E2 (10 micromol/L), prostaglandin F2alpha (10 micromol/L), or buffer alone. RESULTS: Mononuclear leukocytes from women in active labor exhibited a significant attenuation of beta-adrenergic receptor function as a result of reduced adenylyl cyclase activity. This effect could be induced in mononuclear leukocytes from nonlaboring women by preincubation with prostaglandin E but not oxytocin or prostaglandin F. CONCLUSIONS: Prostaglandin E induces heterologous desensitization of the beta-adrenergic receptor system in mononuclear leukocytes, comparable to that seen during labor. We speculate that during labor the elevated levels of prostaglandin E may induce similar effects on the myometrium, thereby decreasing the efficacy of beta-agonists as tocolytics. |
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Authors:
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S J Lye; P Bernstein; M Oskamp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 179 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-23 Completed Date: 1998-12-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1168-74 Citation Subset: AIM; IM |
Affiliation:
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Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism Adrenergic beta-Agonists / pharmacology* Cyclic AMP / metabolism Dinoprostone / pharmacology Female Humans Isoproterenol / pharmacology Labor, Obstetric / blood, physiology* Monocytes / drug effects, metabolism Myometrium / drug effects Oxytocics / pharmacology Pregnancy Prostaglandins E / blood* Time Factors Tocolytic Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Oxytocics; 0/Prostaglandins E; 0/Tocolytic Agents; 363-24-6/Dinoprostone; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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