Document Detail

An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG.
MedLine Citation:
PMID:  10798678     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To detect glaucomatous damage to the inner retina using the multifocal electroretinogram (mERG). METHODS: The stimulus array consisted of 103 hexagons with a mean luminance of 100 cd/m2 and a contrast of 50%. The mERG was recorded from 13 control subjects, 18 patients with open-angle glaucoma (OAG), 4 glaucoma suspects, and one patient with ischemic optic neuropathy (ION). Individual responses, as well as responses summed within quadrants or across the entire array, were measured in a number of ways. Humphrey visual fields were obtained for all patients, and the mean total deviation (MD) values for the 18 patients with OAG ranged from -2.2 to -18.2 with a mean (SD) of -7.3 (4.5). RESULTS: The mERG measure that best discriminated between the patients and the control subjects was the ratio of the amplitude at 8 msec after the peak response to the amplitude at the peak. Although the value of this ratio fell below the median of the control group for 16 of the 18 OAG patients, only 6 of these patients had ratios that fell below the normal range. Other measures of first- and second-order kernels did not do as well. Both within and across patients, the correlation between local field loss and the mERG ratio measure was poor. Furthermore, although in some patients the mERG waveform is clearly different from normal, in other patients (including the patient with ION) the waveform approximates the normal even in visual field areas with substantial sensitivity loss. CONCLUSIONS: Because glaucomatous damage is known to affect the ganglion cell axon, these data suggest that damage to ganglion cell axons is not a sufficient condition to produce changes in the mERG as measured here and that in patients with clear changes in mERG waveforms, these changes do not appear to be well localized and local waveforms are poorly correlated with local changes in field sensitivity.
D C Hood; V C Greenstein; K Holopigian; R Bauer; B Firoz; J M Liebmann; J G Odel; R Ritch
Related Documents :
15854068 - Visual experience during cataract surgery: a nation-wide survey on the knowledge of opt...
19922088 - Three-dimensional video-oculography in patients with vestibular neuritis.
20720228 - The transition zone between healthy and diseased retina in patients with retinitis pigm...
19726938 - Neuro-ophthalmologic features of spinocerebellar ataxia type 7.
158448 - Immunological and purine enzyme studies on hyperuricaemic and normouricaemic patients w...
7859528 - Manometric characteristics of the pharynx, upper esophageal sphincter, esophagus, and l...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  41     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-15     Completed Date:  2000-05-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1570-9     Citation Subset:  IM    
Department of Psychology, Columbia University, New York, New York 10027, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Electroretinography / methods*
Glaucoma, Open-Angle / diagnosis*
Middle Aged
Ocular Hypertension / diagnosis
Retinal Ganglion Cells / pathology*
Visual Acuity
Visual Fields
Grant Support
R01-EY-02115/EY/NEI NIH HHS; R01-EY-09076/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative MR imaging study of intravitreal sustained release of VEGF in rabbits.
Next Document:  An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to ...