Document Detail

Is atrial fibrillation associated with poor outcome after thrombolysis?
MedLine Citation:
PMID:  20127250     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation (AF) is considered a predictor for severe stroke and poor outcome. The aim was to evaluate whether AF is associated with poor outcome in acute ischemic stroke (IS) patients treated with intravenous thrombolysis (IVT). In a retrospective study, 157 consecutive IS patients (98 males, mean age 67.3 +/- 10.2 years), treated with IVT within 3 hours from stroke onset, were divided into two groups according to presence/absence of AF. Neurological deficit was evaluated using the NIHSS on admission, 24 hours, and 7 days later, while the 90-day clinical outcome was assessed using the modified Rankin Scale (mRS). A total of 66 patients (38 males) presented with AF. The baseline NIHSS was 13.3 +/- 5.4 in AF and 11.0 +/- 5.1 points in non-AF patients (P = 0.006). AF patients had arterial occlusions more frequently in the baseline MRA (54.5% in AF versus 25.3% in non-AF, P = 0.0002). No differences were found between groups in clinical improvement after 24 hours and 7 days or in rate of achieved recanalizations. AF patients had significantly poorer 90-day clinical outcome than non-AF patients (median mRS 2.5 vs. 1.0). Patients with AF had significantly worse 90-day clinical outcome after IVT compared to those without AF, probably due to more severe baseline neurological deficits and the greater number of arterial occlusions in the MRA before IVT.
Daniel Sanák; Roman Herzig; Michal Král; Andrea Bártková; Jana Zapletalová; Martin Hutyra; David Skoloudík; Ivanka Vlachová; Tomás Veverka; David Horák; Petr Kanovský
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-02
Journal Detail:
Title:  Journal of neurology     Volume:  257     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  999-1003     Citation Subset:  IM    
Stroke Center, Department of Neurology, Palacký University Medical School and University Hospital, I. P. Pavlova 6, 77520 Olomouc, Czech Republic.
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MeSH Terms
Acute Disease
Aged, 80 and over
Atrial Fibrillation* / complications
Brain Ischemia / diagnosis,  drug therapy*,  physiopathology*
Middle Aged
Retrospective Studies
Severity of Illness Index
Stroke / diagnosis,  drug therapy*,  physiopathology*
Thrombolytic Therapy* / methods
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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