Document Detail


The athlete, cocaine, and lactic acidosis: a hypothesis.
MedLine Citation:
PMID:  3321984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The muscular makeup of the sprint-trained athlete may make him especially susceptible to severe lactic acidosis from cocaine-induced seizures. Because of a high percentage of glycolytic muscle fibers (compared to the muscle fiber type of the endurance-trained athlete), the lactic acidosis and heat generated from muscular activity is much greater in the sprint-trained athlete than in the endurance-trained athlete. The role of cocaine in producing seizures and increasing glycolysis, both of which produce lactic acidosis, is discussed. The hypothesis is presented that the elite athlete may be at greater risk of death than the general population from lactic acidosis produced as a result of cocaine-induced seizures.
Authors:
R A Giammarco
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  294     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-28     Completed Date:  1988-01-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  412-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, State University of New York, Health Science Center, Syracuse 13210.
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MeSH Terms
Descriptor/Qualifier:
Acidosis, Lactic / etiology*,  physiopathology
Cocaine*
Doping in Sports*
Glycolysis
Humans
Muscles / anatomy & histology,  physiology
Physical Education and Training
Seizures / complications
Chemical
Reg. No./Substance:
50-36-2/Cocaine
Comments/Corrections
Erratum In:
Am J Med Sci 1988 May;295(5):476

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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