Document Detail


Is an atherogenic lipoprotein profile in the fetus a prerequisite for placental vascular disease?
MedLine Citation:
PMID:  10759270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To measure the blood apolipoprotein A-1 and apolipoprotein B in the fetal circulation in normal pregnancy and in pregnancy with evidence of vascular disease in the fetal umbilical placental circulation defined in the antenatal period by Doppler ultrasound study. DESIGN: An observational study to compare fetal plasma apolipoprotein levels in normal and complicated pregnancy. SETTING: A university hospital tertiary referral obstetric unit. SAMPLES: Umbilical vein blood was collected at delivery from 22 normal fetuses delivered by elective caesarean section for non fetal reasons and 30 fetuses with evidence of umbilical placental vascular disease identified antenatally by Doppler ultrasound study. METHODS: Plasma apolipoprotein A-1 and B were determined using an enzyme-linked immunosorbent assay (ELISA) methods. MAIN OUTCOME MEASURES: Fetal plasma levels of apolipoprotein A-1 and B were measured. RESULTS: There was a significantly lower level of fetal plasma apolipoprotein A-1 in placental insufficiency [placental insufficiency vs normal pregnancy, median 0.30 g/L (interquartile range 0.24, 0.39 g/L) vs 0.35 g/L (0.31, 0.42 g/L), P = 0.045]. In contrast, the levels of fetal plasma apolipoprotein B in placental insufficiency [0.20 g/L (0.17, 0.26 g/L)] were significantly increased compared with normal pregnancy [0.16 g/L (0. 14, 0.20 g/L), P = 0.03]. The ratio of fetal plasma apolipoprotein B to A-1 was also substantially higher in placental insufficiency [0.68 (0.55, 0.83)] than in normal pregnancy [0.45 (0.36, 0.60), P = 0.0003]. CONCLUSIONS: Our study has demonstrated that levels of fetal plasma apolipoprotein A-1, apolipoprotein B and the ratio of apolipoprotein B to A-1 were altered in the fetuses who are victims of umbilical placental insufficiency in the same direction as in adults associated with a high risk of atherogenesis.
Authors:
J Wang; B Trudinger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  107     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-20     Completed Date:  2000-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  508-13     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins A / blood*
Apolipoproteins B / blood*
Biological Markers / blood
Female
Fetal Blood / chemistry*
Humans
Placental Insufficiency / blood*
Pregnancy
Pregnancy Complications
Pregnancy Trimester, Third / blood
Ultrasonography, Prenatal
Umbilical Cord / ultrasonography
Vascular Diseases / blood*
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Apolipoproteins B; 0/Biological Markers

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