| The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality. | |
| | |
MedLine Citation:
|
PMID: 20228406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Moderately elevated levels of plasma plant sterols have been suspected to be causally involved in atherosclerosis. The aim of this study was to investigate whether plant sterols and other markers of sterol metabolism predicted all-cause and cardiovascular mortality in participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. A total of 1,257 individuals who did not use statins and at baseline had a mean (+/- SD) age of 62.8 (+/- 11.0) years were included in the present analysis. Lathosterol, cholestanol, campesterol, and sitosterol were measured to estimate cholesterol synthesis and absorption. The mean (+/- SD) time of the follow-up for all-cause and cardiovascular mortality was 7.32 (+/- 2.3) years. All-cause (P = 0.001) and cardiovascular (P = 0.006) mortality were decreased in the highest versus the lowest lathosterol to cholesterol tertile. In contrast, subjects in the third cholestanol to cholesterol tertile had increased all-cause (P < 0.001) and cardiovascular mortality (P = 0.010) compared with individuals in the first tertile. The third campesterol to cholesterol tertile was associated with increased all-cause mortality (P = 0.025). Sitosterol to cholesterol tertiles were not significantly related to all-cause or cardiovascular mortality. The data suggest that high absorption and low synthesis of cholesterol predict increased all-cause and cardiovascular mortality in LURIC participants. |
| | |
Authors:
|
Guenther Silbernagel; Guenter Fauler; Michael M Hoffmann; Dieter Lütjohann; Bernhard R Winkelmann; Bernhard O Boehm; Winfried März |
Related Documents
:
|
2721806 - Stratum corneum lipids in skin xerosis. 8263786 - An alternative mechanism for the inhibition of cholesterol biosynthesis in hepg2 cells ... 17033296 - Cholesterol absorption. 3395406 - Biliary lathosterol and other cholesterol precursor sterols are increased in patients w... 17367996 - Effect of lactobacillus johnsonii la1 on immune function and serum albumin in aged and ... 11132846 - Short communication: prepartum photoperiod effect on milk yield and composition in dair... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-14 |
Journal Detail:
|
Title: Journal of lipid research Volume: 51 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-15 Completed Date: 2010-10-20 Revised Date: 2011-08-03 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
|
Languages: eng Pagination: 2384-93 Citation Subset: IM |
Affiliation:
|
Division of Endocrinology, Department of Internal Medicine, Eberhard-Karls-University, Tübingen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Cardiovascular Diseases / blood, diagnosis, metabolism*, mortality* Cholestanol / metabolism Cholesterol / analogs & derivatives, biosynthesis, blood, metabolism* Humans Male Middle Aged Phytosterols / blood* Prognosis Risk Sitosterols / blood |
| Chemical | |
Reg. No./Substance:
|
0/Phytosterols; 0/Sitosterols; 474-62-4/campesterol; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 80-97-7/Cholestanol; 80-99-9/lathosterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of combination lipid therapy in type 2 diabetes mellitus.
Next Document: Crystal structure of the nonerythroid alpha-spectrin tetramerization site reveals differences betwee...