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The associations between high-density lipoprotein mean particle size and its fatty acid composition.
MedLine Citation:
PMID:  23547819     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim: High-density lipoprotein (HDL) particles are heterogeneous in their composition, structure and size and may differ in conferring protection against coronary artery disease. The aim of this study is to investigate the associations between HDL size and its fatty acid composition. Patients & methods: HDL mean particle size from 140 healthy men was detected by dynamic light scattering methodology and fatty acid composition of HDL was determined by gas chromatography. Results: HDL with smaller size had a higher proportion of saturated fatty acids and lower proportion of unsaturated fatty acids. HDL mean size indicated a negative correlation with palmitic acid (r = -0.17; p < 0.05) and a positive correlation with palmitoleic acid (r = 0.17; p < 0.05), oleic acid (r = 0.23; p < 0.01), arachidonic acid (r = 0.17; p < 0.05) and dihomogamalinoleic acid (r = -0.18; p < 0.05). Conclusion: Saturated fatty acids of HDL are inversely assocaited and unsaturated fatty acids are directly associated with HDL mean size.
Authors:
Amirnader Emami Razavi; Morteza Pourfarzam; Mohsen Ani; Gholam Ali Naderi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  7     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  235-45     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
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