| The association of thyroid function with carotid artery plaque burden and strokes in a population-based sample from a previously iodine-deficient area. | |
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MedLine Citation:
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PMID: 18495692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Thyroid dysfunction is associated with detrimental cardiovascular effects. We analyzed whether thyroid status is related to carotid artery plaques and prevalent strokes. DESIGN, PATIENTS AND MEASUREMENTS: Data from 2128 subjects (1157 men and 971 women) aged > or =45 years without thyroid diseases participating in the Study of Health in Pomerania were analyzed. The presence of carotid plaques was assessed by B-mode ultrasound and prevalent stroke was assessed by interview. The sample was divided according to the reference range of serum TSH levels into decreased (<0.25 mIU/l), normal (0.25-2.12 mIU/l), and elevated (>2.12 mIU/l). Logistic regression models were adjusted for common confounders including age, sex, BMI, hypertension, diabetes mellitus, smoking, school education, plasma fibrinogen and serum cholesterol levels, and statins. RESULTS: The prevalence of carotid plaques at any site was higher in subjects with decreased serum TSH levels (81.7%) compared with normal serum TSH levels (70.2%) and elevated serum TSH levels (65.6%; P<0.001). Fully adjusted logistic regression models revealed increased odds for carotid plaques (odds ratio (OR) 1.67; 95% confidence interval (CI) 1.11-2.51; P<0.05) as well as for prevalent strokes (OR 1.98; 95% CI 1.05-3.73; P<0.05) in subjects with decreased serum TSH levels, while there was no association between elevated serum TSH levels and carotid plaques or stroke respectively. CONCLUSIONS: Thyroid function was associated with the presence of carotid artery plaques and prevalent strokes in this population-based sample. Periodical screening and early treatment of atherosclerotic risk factors should be performed in subjects with decreased serum TSH levels. |
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Authors:
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Marcus Dörr; Klaus Empen; Daniel M Robinson; Henri Wallaschofski; Stephan B Felix; Henry Völzke |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-21 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 159 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Institute for Community Medicine, Ernst-Moritz-Arndt-University, 17475 Greifswald, Germany. mdoerr@uni-greifswald.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carotid Stenosis / blood, epidemiology* Case-Control Studies Female Geography Humans Iodine / deficiency* Male Middle Aged Odds Ratio Population Stroke / blood, epidemiology* Thyroid Diseases / blood, epidemiology Thyroid Function Tests Thyroid Gland / physiology* Thyrotropin / blood |
| Chemical | |
Reg. No./Substance:
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7553-56-2/Iodine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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