| The association of sudden cardiac death with inflammation and other traditional risk factors. | |
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MedLine Citation:
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PMID: 18769368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the frequency of cardiovascular death in dialysis patients, few studies have prospectively measured sudden cardiac death in these individuals. Here, we sought to determine the frequency of sudden cardiac death and its association with inflammation and other risk factors among the CHOICE (Choices for Healthy Outcomes In Caring for ESRD) cohort of 1,041 incident dialysis patients. Sudden cardiac death was defined as that occurring outside of the hospital with an underlying cardiac cause from death certificate data. Over a median 2.5 years of follow-up, 22% of all mortality in this cohort was due to sudden cardiac death. Using Cox proportional hazards, we found that the highest tertiles of high-sensitivity C-reactive protein and of IL-6 were each associated with twice the risk of sudden cardiac death compared to their lowest tertiles when adjusted for demographics, comorbidities and laboratory factors. A decrement in serum albumin was associated with a 1.35 times increased risk for sudden cardiac death in the highest compared to the lowest tertile. These findings were robust and consistent when accounting for competing risks of death from other causes. Hence, we found that sudden cardiac death is common among patients with end stage renal disease and that inflammation and malnutrition significantly increased its occurrence independent of traditional cardiovascular risk factors. |
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Authors:
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Rulan S Parekh; Laura C Plantinga; W H Linda Kao; Lucy A Meoni; Bernard G Jaar; Nancy E Fink; Neil R Powe; Josef Coresh; Michael J Klag |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-09-03 |
Journal Detail:
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Title: Kidney international Volume: 74 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-31 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 1335-42 Citation Subset: IM |
Affiliation:
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Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. rsparekh@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged C-Reactive Protein / analysis Cause of Death Cohort Studies Death, Sudden, Cardiac / etiology* Female Humans Inflammation / complications* Interleukin-6 / blood Kidney Failure, Chronic / complications* Male Middle Aged Renal Dialysis Risk Factors Serum Albumin |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 DK070657-01/DK/NIDDK NIH HHS; 1UO1-DK-57304-01/DK/NIDDK NIH HHS; K24-DK-02643/DK/NIDDK NIH HHS; K24-DK-02856/DK/NIDDK NIH HHS; R01-DK-59616/DK/NIDDK NIH HHS; R01-HL-62985/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Serum Albumin; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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