| An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder. | |
| | |
MedLine Citation:
|
PMID: 16829779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: A series of methamphetamine psychosis reveals two kinds of clinical courses of methamphetamine psychosis: transient type and prolonged type. Furthermore, paranoid psychosis sometimes recurs without methamphetamine reuse, referred to as spontaneous relapse. Dysfunction of central dopaminergic neurotransmission has been implicated in the pathogenesis of these psychiatric states. Catechol-O-methyl transferase appears to play a unique role in regulating synaptic dopaminergic activity. This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states. BASIC METHODS: We examined the functional polymorphism of val 158 met (catechol-O-methyl transferase) in 143 patients with methamphetamine psychosis and 200 healthy controls in Japan. The patients were divided into subgroups by several characteristic clinical features. MAIN RESULTS: We found a significant difference in the catechol-O-methyl transferase allele frequency between patients with spontaneous relapse and the controls (P=0.018, odds ratio=1.67). Odds ratio implied that the patients with spontaneous relapse had a nearly 1.7-fold higher rate of the low activity alleles (met) than the controls. CONCLUSIONS: Our results indicate that the met allele frequency of the catechol-O-methyl transferase is associated with patients who experienced methamphetamine psychosis and spontaneous relapse, suggesting that patients with a met allele appear to be at increased risk of an adverse response to methamphetamine. |
| | |
Authors:
|
Atsuko Suzuki; Kazuhiko Nakamura; Yoshimoto Sekine; Yoshio Minabe; Nori Takei; Katsuaki Suzuki; Yasuhide Iwata; Masayoshi Kawai; Kiyokazu Takebayashi; Hideo Matsuzaki; Masaomi Iyo; Norio Ozaki; Toshiya Inada; Nakao Iwata; Mutsuo Harano; Tokutaro Komiyama; Mitsuhiko Yamada; Ichiro Sora; Hiroshi Ujike; Norio Mori |
Related Documents
:
|
15229069 - Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schiz... 6625959 - Detoxification treatment for chronic schizophrenic patients: experimental results and d... 19941589 - Prevalence of temporomandibular disorder signs in patients with schizophrenia. 12655909 - Clozapine treatment in patients with prior substance abuse. 22233329 - The pathology and clinical features of early recurrent membranous glomerulonephritis. 20505069 - Resting-state perfusion in nonmedicated schizophrenic patients: a continuous arterial s... 22244549 - Raised erythrocyte creatine in patients with pulmonary arterial hypertension - evidence... 6831169 - The reasons for persistent hypercalcaemia after cervical exploration for presumed prima... 3711379 - Puva therapy for psoriasis: comparison of oral and bath-water delivery of 8-methoxypsor... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Psychiatric genetics Volume: 16 ISSN: 0955-8829 ISO Abbreviation: Psychiatr. Genet. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-07-10 Completed Date: 2006-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9106748 Medline TA: Psychiatr Genet Country: England |
Other Details:
|
Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, and Ichihara Hospital, Chiba, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Catechol O-Methyltransferase / genetics* Female Gene Frequency Genotype Humans Male Methamphetamine / toxicity* Middle Aged Polymorphism, Genetic* Psychotic Disorders / etiology*, genetics* Recurrence Reference Values |
| Chemical | |
Reg. No./Substance:
|
537-46-2/Methamphetamine; EC 2.1.1.6/Catechol O-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tobacco use cessation within the context of tobacco control policy: opportunities for nursing resear...
Next Document: Dopamine D4 receptor gene and the -521C>T polymorphism of the upstream region of the dopamine D4 rec...