| The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 Diabetes. | |
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MedLine Citation:
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PMID: 21958081 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To determine whether circulating metabolic intermediates are associated with inflammation, oxidative stress, and arterial stiffness in men with newly-diagnosed type 2 diabetes, and investigate the circulating metabolic intermediates that may predict the risk of developing diabetes. Research Design and Methods: Men with newly-diagnosed type 2 diabetes (n=26) and age- and body mass index-matched non-diabetic men (n=27) were included. We measured inflammatory and oxidative markers and arterial stiffness by brachial-ankle pulse wave velocity (ba-PWV). Metabolomic profiling was analyzed with ultra performance liquid chromatography and quadrupole time-of-flight mass spectrometry. Results: Diabetic men showed higher circulating levels of glucose, triglyceride, oxidized low density lipoprotein (LDL), high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha (TNF-α), homeostasis model assessment-insulin resistance, urinary 8-epi-prostaglandin F(2α) (8-epi-PGF(2α) ), and ba-PWV than non-diabetic men. In plasma, 19 metabolites including 3 amino acids, 8 acylcarnitines, 6 lyso-phosphatidylcholines (lysoPCs), and 2 lyso-phosphatidylethanolamines (lysoPEs; C18:2 and C22:6) significantly increased in diabetes men, whereas serine and lysoPE (C18:1) decreased. Decanoyl carnitine, lysoPCs (C14:0, C16:1, C18:1, and C22:6), and lysoPE (C18:1) with variable importance in the projection values >1.0 were major plasma metabolites that distinguished non-diabetic and diabetic men. Decanoyl carnitine positively correlated with oxidized-LDL, 8-epi-PGF(2α) , interleukin-6, TNF-α, and ba-PWV. Ba-PWV correlated positively with lysoPCs C14:0 and C16:1, and negatively with lysoPE C18:1. 8-epi-PGF(2α) correlated positively with lipoprotein-associated phospholipaseA(2) , ba-PWV, and lysoPCs (C14:0 and C16:1). The receiver operating characteristic curve estimation suggested that decanoyl carnitine and lysoPC (C14:0) are the best metabolites for predicting the risk of developing diabetes. Conclusions: Circulating lipid-related intermediate metabolites can be closely associated with inflammation, oxidative stress, and arterial stiffness in early diabetes. |
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Authors:
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Chang Young Ha; Ji Young Kim; Jean Kyung Paik; Oh Yoen Kim; Yong-Han Paik; Eun Jig Lee; Jong Ho Lee |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Interdisciplinary Course of Science for Aging, Graduate School, Yonsei University, Seoul, Korea Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Dept. of Food & Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine Gangnam Severance Hospital, Seoul, Korea Division of Endocrinology, Yonsei University College of Medicine, Seoul, Korea. |
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