Document Detail


The association of serum uric acid levels with outcomes following percutaneous coronary intervention.
MedLine Citation:
PMID:  20636849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Serum uric acid may serve as a marker for the activation of oxidative stress and may therefore be a marker for subsequent cardiovascular events. Our goal was to assess the association of serum uric acid levels and the outcomes of patients who have undergone percutaneous coronary intervention (PCI).
METHODS: We performed a retrospective cohort study of patients who underwent PCI between 1/1/2000 and 12/31/2007. Data were retrieved from the Cardiac Lab Interventional Clinical Database as well as the medical records. Outcomes of mortality as well as major adverse cardiac events (MACE) that include death, myocardial infarction (MI), and target vessel revascularization were obtained. There were 10,632 unique patients who had a PCI at the Mayo Clinic in Rochester and allowed use of their records for research. During this time, 1,916 had a uric acid measure within 2 years prior to the day of PCI.
RESULTS: Of the 1,916 patients in our cohort, 1,353 had normal uric acid levels and 563 had elevated uric acid. After multivariable analysis, there was a strong trend in association with follow-up mortality in patients with elevated uric acid (HR = 1.25, 95% CI 0.98-1.59, P = 0.07). The association with mortality or MI (HR = 1.15, 95% CI 0.93-1.43, P = 0.20) and the association with MACE (HR = 1.04, CI 0.86- 1.25, P = 0.71) were not significant.
CONCLUSIONS: In a large single-center database with complete follow-up, elevated serum uric acid was associated with increased mortality in PCI patients. These data show a trend for uric acid in the pathophysiology of atherosclerotic coronary artery disease and highlight the need for further research.
Authors:
Daniel B Spoon; Amir Lerman; Andrew D Rule; Abhiram Prasad; Ryan J Lennon; David R Holmes; Charanjit S Rihal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  23     ISSN:  1540-8183     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2011-06-21     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Balloon, Coronary / adverse effects*
Cohort Studies
Confidence Intervals
Coronary Artery Disease / mortality,  therapy*
Databases, Factual
Female
Humans
Hyperuricemia / chemically induced*,  mortality
Inflammation
Kaplan-Meier Estimate
Logistic Models
Male
Multivariate Analysis
Myocardial Infarction / mortality,  therapy*
Oxidative Stress*
Retrospective Studies
Risk Factors
Statistics as Topic
Treatment Outcome
Uric Acid / blood*,  metabolism
Grant Support
ID/Acronym/Agency:
K23 DK078229/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
268B43MJ25/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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