| The association of serum uric acid levels with outcomes following percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 20636849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum uric acid may serve as a marker for the activation of oxidative stress and may therefore be a marker for subsequent cardiovascular events. Our goal was to assess the association of serum uric acid levels and the outcomes of patients who have undergone percutaneous coronary intervention (PCI). METHODS: We performed a retrospective cohort study of patients who underwent PCI between 1/1/2000 and 12/31/2007. Data were retrieved from the Cardiac Lab Interventional Clinical Database as well as the medical records. Outcomes of mortality as well as major adverse cardiac events (MACE) that include death, myocardial infarction (MI), and target vessel revascularization were obtained. There were 10,632 unique patients who had a PCI at the Mayo Clinic in Rochester and allowed use of their records for research. During this time, 1,916 had a uric acid measure within 2 years prior to the day of PCI. RESULTS: Of the 1,916 patients in our cohort, 1,353 had normal uric acid levels and 563 had elevated uric acid. After multivariable analysis, there was a strong trend in association with follow-up mortality in patients with elevated uric acid (HR = 1.25, 95% CI 0.98-1.59, P = 0.07). The association with mortality or MI (HR = 1.15, 95% CI 0.93-1.43, P = 0.20) and the association with MACE (HR = 1.04, CI 0.86- 1.25, P = 0.71) were not significant. CONCLUSIONS: In a large single-center database with complete follow-up, elevated serum uric acid was associated with increased mortality in PCI patients. These data show a trend for uric acid in the pathophysiology of atherosclerotic coronary artery disease and highlight the need for further research. |
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Authors:
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Daniel B Spoon; Amir Lerman; Andrew D Rule; Abhiram Prasad; Ryan J Lennon; David R Holmes; Charanjit S Rihal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 23 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2011-06-21 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 277-83 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Disease and Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary / adverse effects* Cohort Studies Confidence Intervals Coronary Artery Disease / mortality, therapy* Databases, Factual Female Humans Hyperuricemia / chemically induced*, mortality Inflammation Kaplan-Meier Estimate Logistic Models Male Multivariate Analysis Myocardial Infarction / mortality, therapy* Oxidative Stress* Retrospective Studies Risk Factors Statistics as Topic Treatment Outcome Uric Acid / blood*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK078229-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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