| The association of serum prolidase activity with the presence and severity of coronary artery disease. | |
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MedLine Citation:
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PMID: 18607169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with carboxy-terminal proline or hydroxyproline and plays major role in collagen turnover. Collagen is the essential content in atherosclerotic plaque playing a key role in the stability/instability of and progression of coronary artery disease (CAD). Consequently, in this study we sought to determine serum prolidase activity and markers of oxidative stress such as lipid hydroperoxide and total free sulfhydryl in CAD. DESIGN AND METHODS: We have evaluated 199 patients with CAD and 122 control cases with clinical, electrocardiographic, and laboratory investigation. We have measured serum prolidase activity and serum total free sulfhydryl levels spectrophotometrically. Serum lipid hydroperoxide levels were determined with ferrous ion oxidation-xylenol orange method. We assessed the association of serum prolidase activity with the presence and severity of CAD and clinical characteristics, and laboratory parameters. RESULTS: Serum prolidase activity (52.5+/-5.6 vs. 46.7+/-5.1 U/l, respectively, P<0.001) and serum lipid hydroperoxide levels were significantly increased in patients with CAD compared with control cases whereas, serum total free sulfhydryl levels were significantly decreased in patients with CAD compared with control cases. Serum prolidase activity and total free sulfhydryl levels were independent predictors of the presence of CAD [(chi=75.532, ss=0.212, P=0.003) and (chi=25.969, ss=-30.486, P=0.019), respectively] and Gensini score [(beta=0.276, P<0.001) and (beta=-0.274, P<0.001), respectively]. Independent predictors of serum prolidase activity were serum high-density lipoprotein cholesterol (beta=-0.138, P=0.023) and urea levels (beta=0.146, P=0.036), and Gensini score (beta=0.317, P<0.001). CONCLUSION: Findings of this study have shown that serum prolidase activity is significantly associated with the presence and severity of CAD, and elevated serum prolidase activity might be an independent predictor of coronary atherosclerosis. |
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Authors:
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Ali Yildiz; Recep Demirbag; Remzi Yilmaz; Mustafa Gur; Ibrahim H Altiparmak; Selahattin Akyol; Nurten Aksoy; Ali R Ocak; Ozcan Erel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Coronary artery disease Volume: 19 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-08 Completed Date: 2008-11-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 319-25 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Harran University, School of Medicine, Sanliurfa, Turkey. ghcayildiz@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Biological Markers / blood* Case-Control Studies Coronary Angiography Coronary Artery Disease / blood, enzymology*, radiography Dipeptidases / blood*, metabolism Female Humans Linear Models Lipid Peroxides / blood*, metabolism Male Middle Aged Oxidative Stress Serum Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipid Peroxides; EC 3.4.13.-/Dipeptidases; EC 3.4.13.9/proline dipeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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