Document Detail


The association of red blood cell n-3 and n-6 fatty acids with bone mineral density and hip fracture risk in the women's health initiative.
MedLine Citation:
PMID:  23018646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) in red blood cells (RBCs) are an objective indicator of PUFA status and may be related to hip fracture risk. The primary objective of this study was to examine RBC PUFAs as predictors of hip fracture risk in postmenopausal women. A nested case-control study (n = 400 pairs) was completed within the Women's Health Initiative (WHI) using 201 incident hip fracture cases from the Bone Mineral Density (BMD) cohort, along with 199 additional incident hip fracture cases randomly selected from the WHI Observational Study. Cases were 1:1 matched on age, race, and hormone use with non-hip fracture controls. Stored baseline RBCs were analyzed for fatty acids using gas chromatography. After removing degraded samples, 324 matched pairs were included in statistical analyses. Stratified Cox proportional hazard models were constructed according to case-control pair status; risk of fracture was estimated for tertiles of RBC PUFA. In adjusted hazard models, lower hip fracture risk was associated with higher RBC α-linolenic acid (tertile 3 [T3] hazard ratio [HR]: 0.44; 95% confidence interval [CI], 0.23-0.85; p for linear trend 0.0154), eicosapentaenoic acid (T3 HR: 0.46; 95% CI, 0.24-0.87; p for linear trend 0.0181), and total n-3 PUFAs (T3 HR: 0.55; 95% CI, 0.30-1.01; p for linear trend 0.0492). Conversely, hip fracture nearly doubled with the highest RBC n-6/n-3 ratio (T3 HR: 1.96; 95% CI, 1.03-3.70; p for linear trend 0.0399). RBC PUFAs were not associated with BMD. RBC PUFAs were indicative of dietary intake of marine n-3 PUFAs (Spearman's rho = 0.45, p < 0.0001), total n-6 PUFAs (rho = 0.17, p < 0.0001) and linoleic acid (rho = 0.09, p < 0.05). These results suggest that higher RBC α-linolenic acid, as well as eicosapentaenoic acid and total n-3 PUFAs, may predict lower hip fracture risk. Contrastingly, a higher RBC n-6/n-3 ratio may predict higher hip fracture risk in postmenopausal women.
Authors:
Tonya S Orchard; Steven W Ing; Bo Lu; Martha A Belury; Karen Johnson; Jean Wactawski-Wende; Rebecca D Jackson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  28     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-08-29     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society for Bone and Mineral Research.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00000611
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MeSH Terms
Descriptor/Qualifier:
Aged
Bone Density*
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Female
Humans
Prospective Studies
Women's Health
Grant Support
ID/Acronym/Agency:
N01 WH032109/WH/WHI NIH HHS; N01 WH042112/WH/WHI NIH HHS; N01WH22110/WH/WHI NIH HHS; N01WH24152/WH/WHI NIH HHS; N01WH32100/WH/WHI NIH HHS; N01WH32101/WH/WHI NIH HHS; N01WH32102/WH/WHI NIH HHS; N01WH32105/WH/WHI NIH HHS; N01WH32106/WH/WHI NIH HHS; N01WH32108/WH/WHI NIH HHS; N01WH32109/WH/WHI NIH HHS; N01WH32111/WH/WHI NIH HHS; N01WH32112/WH/WHI NIH HHS; N01WH32113/WH/WHI NIH HHS; N01WH32115/WH/WHI NIH HHS; N01WH32118/WH/WHI NIH HHS; N01WH32119/WH/WHI NIH HHS; N01WH32122/WH/WHI NIH HHS; N01WH42107/WH/WHI NIH HHS; N01WH42108/WH/WHI NIH HHS; N01WH42109/WH/WHI NIH HHS; N01WH42110/WH/WHI NIH HHS; N01WH42111/WH/WHI NIH HHS; N01WH42112/WH/WHI NIH HHS; N01WH42113/WH/WHI NIH HHS; N01WH42114/WH/WHI NIH HHS; N01WH42115/WH/WHI NIH HHS; N01WH42116/WH/WHI NIH HHS; N01WH42117/WH/WHI NIH HHS; N01WH42118/WH/WHI NIH HHS; N01WH42119/WH/WHI NIH HHS; N01WH42120/WH/WHI NIH HHS; N01WH42121/WH/WHI NIH HHS; N01WH42122/WH/WHI NIH HHS; N01WH42123/WH/WHI NIH HHS; N01WH42124/WH/WHI NIH HHS; N01WH42125/WH/WHI NIH HHS; N01WH42126/WH/WHI NIH HHS; N01WH42129/WH/WHI NIH HHS; N01WH42130/WH/WHI NIH HHS; N01WH42131/WH/WHI NIH HHS; N01WH42132/WH/WHI NIH HHS; N01WH44221/WH/WHI NIH HHS; TL1 RR025753/RR/NCRR NIH HHS; TL1RR025753/RR/NCRR NIH HHS; UL1 RR025755/RR/NCRR NIH HHS; UL1RR025755/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6
Comments/Corrections

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