Document Detail

The association of race and survival from sepsis after injury.
MedLine Citation:
PMID:  20135938     Owner:  NLM     Status:  MEDLINE    
Genetic variation is associated with outcome disparity in critical illness. We sought to determine if race is independently associated with the development of posttraumatic sepsis and subsequent related mortality. Our Intensive Care Unit database was queried for admissions from January 1, 2000 to June 30, 2007. Patients were prospectively followed for sepsis (Any four of the following symptoms: temperature > or =38 degrees C, heart rate (HR) > or =90 b/m, RR > or =20 b/m (or PaCO2 < or =32 mm Hg), white blood cell count (WBC) > or =12, or vasopressor requirement all with an infectious source). White, Black, Hispanic, and Asian groups were defined. "Other" race was excluded. Most of the 3998 study patients were male (3157, 79.0%). Blunt trauma (2661, 66.6%) predominated. Six-hundred-seventy-seven (16.9%) met sepsis criteria. Mortality was 14.0 per cent (560). Sepsis was increased in Asians versus all others combined (23.7% vs. 16.1%). Race was independently associated with sepsis (adjusted odds ratio (OR) 1.12 (1.01-1.24), P value = 0.03). Sepsis associated mortality was 36.9 per cent (250/677). Black race demonstrated an increased survival versus all others after sepsis (25.4% vs. 37.7%) but this was not statistically significant (adjusted OR 0.96 (0.73-1.18), P value = 0.71). Race is independently associated with posttraumatic sepsis and possibly subsequent sepsis associated mortality. Further related study is needed with the ultimate goal of genetically based treatments for the prevention and treatment of sepsis after injury.
David S Plurad; Thomas Lustenberger; Patrick Kilday; Jay Zhu; Donald J Green; Kenji Inaba; Peep Talving; Howard Belzberg; Demetrios Demetriades
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  76     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Los Angeles County + University of Southern California Medical Center, Division of Trauma/Surgical Critical Care, Los Angeles, California 90033, USA.
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MeSH Terms
African Americans / statistics & numerical data
Asian Americans / statistics & numerical data
European Continental Ancestry Group / statistics & numerical data
Hispanic Americans / statistics & numerical data
Logistic Models
Los Angeles / epidemiology
Middle Aged
Prospective Studies
Sepsis / ethnology*,  etiology,  mortality*
Survival Rate
Wounds and Injuries / complications*,  ethnology,  mortality

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