Document Detail

The association of race and sex to the pressure natriuresis response to stress.
MedLine Citation:
PMID:  17985504     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Sympathetic nervous system activation promoting sodium retention has long been recognized to play a significant role in the development and maintenance of salt-sensitive hypertension. The purpose of this study was to examine the influence of race and sex on the pressure natriuresis response to prolonged behavioral stress in youth. METHODS: The 190 subjects included 94 boys (41 African American, 53 Caucasian) and 96 girls (44 African American, 52 Caucasian) of similar age (17-19 years). The stress test was composed of a one hour competitive video game task preceded and followed by two-hour rest periods. Blood pressure (BP) was obtained at 15 minute intervals and sodium excretion (U(Na)V) was measured hourly. The general linear model was used to model the effects of race, sex, and their interaction on the variables of interest. RESULTS: Caucasians, compared to African Americans, had a greater change in U(Na)V (F[1,183] = 5.28, P = .0227), as did boys compared to girls (F[1,183] = 5.72, P = .0178), with no interaction between race and sex. The race-by-sex interaction was significant for the change in systolic BP (F[1,183] = 5.66, P = .0184), with Caucasian girls showing a smaller change than the other three race/sex groups. CONCLUSION: African Americans have a reduced natriuretic response to stress, which may be a marker or mechanism for the development of salt-sensitive hypertension in this population. The race difference within girls is of interest and requires further investigation.
Gregory A Harshfield; Coral Hanevold; Gaston K Kapuku; Yanbin Dong; Martha E Castles; David A Ludwig
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Ethnicity & disease     Volume:  17     ISSN:  1049-510X     ISO Abbreviation:  Ethn Dis     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-07     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109034     Medline TA:  Ethn Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  498-502     Citation Subset:  IM    
Georgia Prevention Institute, Medical College of Georgia, MCG Annex H.S. 1640, Augusta, GA 30912-4534, USA.
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MeSH Terms
African Americans
Blood Pressure / physiology*
European Continental Ancestry Group
Exercise Test
Natriuresis / physiology*
Sex Factors
Stress, Psychological / physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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