Document Detail


The association of primary hyperparathyroidism with pancreatitis.
MedLine Citation:
PMID:  22874807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between primary hyperparathyroidism (PHPT) and acute or chronic pancreatitis is controversial. For this reason, we conducted a review of the literature over the past 30 years to explore the relationship between these 2 disorders. Ten retrospective studies each with >50 patients diagnosed with PHPT were identified. With the notable exception of 2 studies, the rate of pancreatitis among patients with PHPT was higher than that reported in general among hospitalized patients without PHPT. A higher serum calcium level may contribute to pancreatitis in these cases, along with additional genetic or environmental insults. Hypercalcemia may predispose the pancreatic acinar cell to abnormal, sustained calcium levels, lead to premature pancreatic protease activation, and pancreatitis. Although there was only short-term follow-up, most reports cited that definitive treatment of PHPT by parathyroidectomy led to the resolution of pancreatitis attacks. The published cohorts of patients with PHPT and pancreatitis are subject to bias, because serum calcium screening was not universally performed among all control nonpancreatitis patients to evaluate for PHPT. However, the pooled clinical and experimental data suggest an association between PHPT and pancreatitis and implicate hypercalcemia. For clinicians, it is important to recognize pancreatitis in patients with PHPT and, conversely, to consider PHPT by checking serum calcium levels in patients, who present with an unexplained pancreatitis.
Authors:
Harrison X Bai; Matthew Giefer; Mohini Patel; Abrahim I Orabi; Sohail Z Husain
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  46     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-09     Completed Date:  2013-01-07     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  656-61     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
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MeSH Terms
Descriptor/Qualifier:
Calcium / blood
Humans
Hypercalcemia / complications,  epidemiology
Hyperparathyroidism, Primary / complications*,  epidemiology,  surgery
Pancreatitis / epidemiology,  etiology*
Parathyroid Hormone / blood
Grant Support
ID/Acronym/Agency:
DK083327/DK/NIDDK NIH HHS; DK093491/DK/NIDDK NIH HHS; DK34989/DK/NIDDK NIH HHS; HD001401/HD/NICHD NIH HHS; R01 DK083327/DK/NIDDK NIH HHS; R01 DK093491/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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