Document Detail

The association of peritoneal transport properties with 24-hour blood pressure levels in CAPD patients.
MedLine Citation:
PMID:  12691506     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We aimed to investigate the effects of peritoneal transport characteristics on blood pressure (BP) parameters, measured by 24-hour ambulatory blood pressure monitoring (ABPM), and on the development of left ventricular hypertrophy (LVH) in continuous ambulatory peritoneal dialysis (CAPD) patients. DESIGN: Cross-sectional and prospective design. SETTING: Tertiary-care center. PATIENTS: 25 CAPD patients (11 male, 14 female; mean age 47 +/- 14 years) were included. Mean time on CAPD was 22.9 +/- 18 months and all patients had been dialyzed for more than 6 months. The patients were divided into high, high-average, low-average, and low transport groups according to peritoneal equilibration test results. MAIN OUTCOME MEASURES: Daytime and nighttime systolic and diastolic BP and left ventricular mass index among the different peritoneal transport groups; changes in BP parameters before and after increase in ultrafiltration. RESULTS: On 24-hour ABPM records, 13 patients (52%) were found to be hypertensive. Both mean systolic and diastolic BP were significantly increased in high-transporter groups compared to low transporters in both daytime and nighttime BP parameters. Left ventricular mass index was higher in high transporters compared to low transporters, without reaching statistical significance: 160 +/- 23 vs 119 +/- 41 g/m2, p > 0.05. Following increase in ultrafiltration, mean systolic (145 +/- 13 vs 128 +/- 5 mmHg, p < 0.001) and diastolic (96 +/- 10 vs 81 +/- 3 mmHg, p < 0.001) BP decreased, and BP levels returned to normotensive levels in 6 (46%) of the 13 hypertensive patients, requiring discontinuation of antihypertensive drugs. CONCLUSION: Improvement in volume status resulted in a decrease in both daytime and nighttime BP. Differences in peritoneal transport properties were associated with the development of hypertension and LVH.
Zeki Tonbul; Lutfullah Altintepe; Cetin Sözlü; Mehdi Yeksan; Alaattin Yildiz; Süleyman Türk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  23     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-04-14     Completed Date:  2003-07-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Division of Nephrology, Department of Internal Medicine, Selcuk University Medical School, Konya, Turkey.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory*
Cross-Sectional Studies
Hypertension / complications,  physiopathology*
Hypertrophy, Left Ventricular / complications,  physiopathology*
Kidney Failure, Chronic / complications,  therapy*
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Peritoneum / physiology,  physiopathology*
Prospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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