Document Detail

The association of microalbuminuria with aortic stiffness is independent of C-reactive protein in essential hypertension.
MedLine Citation:
PMID:  19629049     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has not been fully elucidated whether microalbuminuria (MAU) and high-sensitivity C-reactive protein (hsCRP) are associated with aortic distensibility independently of each other. Our study was aimed to evaluate the independent relationships of urinary albumin excretion rate (AER) and hsCRP with aortic stiffness in hypertensive patients.
METHODS: We enrolled 140 untreated nondiabetic essential hypertensives (mean age: 48 +/- 12 years). In all subjects, 24-hour AER and plasma levels of hsCRP were determined by immunoenzymatic assay. MAU was defined as an AER of 20-200 microg/min. Aortic stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV).
RESULTS: Carotid-femoral PWV, adjusted for age and mean arterial pressure (MAP), was higher in subjects with MAU (n = 41) than in those without it (n = 99) (11.6 +/- 2.3 vs. 9.9 +/- 1.8 m/s; P < 0.001) and in subjects with hsCRP above the median value when compared to those with lower levels of hsCRP (10.8 +/- 2.1 vs. 10 +/- 2.1 m/s; P = 0.026). In multiple regression analysis, AER and hsCPR remained independent predictors of aortic stiffness (beta = 0.24; P < 0.001 and beta = 0.15; P = 0.03, respectively).
CONCLUSIONS: Our results suggest that in patients with essential hypertension, MAU and CRP are independently associated with an increased aortic stiffness.
Giuseppe Mulè; Santina Cottone; Paola Cusimano; Raffaella Riccobene; Alessandro Palermo; Calogero Geraci; Emilio Nardi; Tania Bellavia; Anna C Foraci; Giovanni Cerasola
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Publication Detail:
Type:  Journal Article     Date:  2009-07-23
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-24     Completed Date:  2010-01-14     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-7     Citation Subset:  IM    
Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Cattedra di Medicina Interna, European Society of Hypertension Excellence Centre, Università di Palermo, Palermo, Italy.
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MeSH Terms
Albuminuria / complications*
Aorta / physiopathology*
C-Reactive Protein / metabolism*
Heart Rate
Hypertension / blood*,  complications,  physiopathology*
Middle Aged
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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