Document Detail

The association of menstrual cycle, pregnancy, and menopause with recurrent oral aphthous stomatitis: a review and critique.
MedLine Citation:
PMID:  1495706     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine critically the postulated associations between recurrent aphthous stomatitis and the menstrual cycle, pregnancy, and menopause, and to determine why such associations had been accepted previously in the absence of convincing evidence. DATA SOURCES: We used MEDLINE data base searches in 1988 and 1991 to identify all articles since 1966 referring to estrogen, progesterone, menstruation, menstrual cycle, menopause, or pregnancy, and to aphthous stomatitis. Similar searches were carried out in the Index to Dental Literature for the period 1942-1991, and in MEDLINE on CD-ROM in 1991. Articles uncovered were examined for further appropriate references in the 50-year period 1942-1991. We excluded letters, abstracts, and articles in journals that are not peer-reviewed. METHODS OF STUDY SELECTION: We discovered one retrospective study on aphthous ulceration and ovarian hormones, eight prospective studies, three uncontrolled trials on the use of hormones in aphthous stomatitis, one controlled trial, and four review papers. DATA EXTRACTION AND SYNTHESIS: Each paper was carefully read, in translation where necessary, and opinions and findings were critically examined for source, authenticity, and statistical analysis. Each paper was also examined critically in terms of its review and acceptance of previous papers. The papers were too diverse in nature to permit a structured criticism. CONCLUSIONS: No associations have been established between aphthous stomatitis and the premenstrual period, pregnancy, or menopause. No properly designed study has shown a therapeutic effect of ovarian hormones on aphthous stomatitis. Reasons for this lack and the need for large-scale studies are identified.
B E McCartan; A Sullivan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  80     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-8     Citation Subset:  AIM; IM    
School of Dental Science, Trinity College, Dublin, Ireland.
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MeSH Terms
Gonadal Steroid Hormones / therapeutic use
Menstrual Cycle*
Stomatitis, Aphthous* / drug therapy
Reg. No./Substance:
0/Gonadal Steroid Hormones

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