Document Detail

The association of lung disease with cerebral white matter abnormalities in preterm infants.
MedLine Citation:
PMID:  19564309     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Preterm infants have a high incidence of neurodevelopmental impairment associated with diffuse cerebral white matter abnormalities and also a high incidence of serious respiratory disease. However, it is unclear if lung disease and brain injury are related, and previous research has been impeded by confounding effects, including prematurity and infection. Using a new approach that permits multivariate statistical analysis, we tested the hypothesis that lung disease is associated with specific white matter abnormalities, detected as reduced fractional anisotropy (FA) in diffusion tensor imaging data.
METHODS: Fifty-three preterm infants with no evidence of focal abnormality on conventional MRI were studied at term-equivalent age by using tract-based spatial statistics, an automated observer-independent method for voxelwise analysis of major white matter pathways.
RESULTS: In several white matter tracts, FA decreased with a linear relation to the gestational age at birth. Independent of the confounding effects of prematurity and age at scan, respiratory disease was associated with specific white matter abnormalities in preterm infants; those infants receiving mechanical ventilation for >2 days in the perinatal period (n = 10) showed reduced FA in the genu of the corpus callosum, whereas subjects with chronic lung disease (n = 15) displayed a reduction in FA in the left inferior longitudinal fasciculus.
CONCLUSION: Independent of the degree of prematurity, respiratory disease is associated with cerebral white matter abnormalities.
Mustafa Anjari; Serena J Counsell; Latha Srinivasan; Joanna M Allsop; Joseph V Hajnal; Mary A Rutherford; A David Edwards
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatrics     Volume:  124     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-09-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  268-76     Citation Subset:  AIM; IM    
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MeSH Terms
Cerebrum / pathology*
Corpus Callosum / pathology
Developmental Disabilities / pathology*
Diffusion Magnetic Resonance Imaging / methods*
Gestational Age
Image Processing, Computer-Assisted / methods*
Infant, Newborn
Infant, Premature*
Lung Diseases / epidemiology*,  pathology*
Multivariate Analysis
Neural Pathways / pathology*
Respiration, Artificial
Grant Support
MC_U120061309//Medical Research Council; MC_U120081323//Medical Research Council; MC_U120088465//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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