Document Detail

The association of low serum cholesterol with depression and suicidal behaviours: new hypotheses for the missing link.
MedLine Citation:
PMID:  11191718     Owner:  NLM     Status:  MEDLINE    
Several observational studies indicate that reduction of serum cholesterol levels is related to an increase in violent deaths and suicide but the nature of this possible relationship remains unclear. Many confounding factors, e.g. poor health, depression and loss of appetite may play a role in the apparent relationship between serum cholesterol levels and suicide. Two separate phenomena should be considered: lowering total cholesterol and low total cholesterol. This review considers the evidence from epidemiological studies on serum cholesterol lowering and psychiatric disturbances. The available evidence does not seem to substantiate the view that large-scale intervention to reduce cholesterol concentrations could lead to more violent and aggressive behaviour, and generally greater unhappiness. In recent trials using statin treatment, there were slightly fewer deaths from accidents and suicide in the treated group compared with the placebo group. We believe that clinicians should not be deterred from prescribing cholesterol-lowering drugs, to reduce the risk of death from coronary heart disease, when they are indicated.
R Manfredini; S Caracciolo; R Salmi; B Boari; A Tomelli; M Gallerani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of international medical research     Volume:  28     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-01-12     Completed Date:  2001-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-57     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, University of Ferrara, Italy.
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MeSH Terms
Anticholesteremic Agents / adverse effects
Cardiovascular Diseases / blood,  etiology,  prevention & control
Cholesterol / blood*
Depression / blood*,  etiology
Hypercholesterolemia / complications,  drug therapy
Models, Psychological
Reg. No./Substance:
0/Anticholesteremic Agents; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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