Document Detail


The association of increased levels of intermediate-density lipoproteins with smoking and with coronary artery disease.
MedLine Citation:
PMID:  3791598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were undertaken to determine whether there is an association between elevated levels of intermediate-density lipoproteins (IDL) (Sf 12-60 lipoproteins) and coronary artery disease. Forty-five to sixty-five-year-old men with objectively documented coronary artery disease (n = 58) who were free of known risk factors (diabetes, hypertension, obesity, hyperuricemia, and hypercholesterolemia) were compared with similar men who were free of coronary artery disease (n = 52). Smokers could not be excluded. The coronary artery disease group had a higher rate of cigarette smoking (NS, due to large variations); higher concentrations of triglycerides in their plasma (p = .003) and higher levels of very low-density lipoproteins (VLDL) (p = .007), IDL (p = .016), and low-density lipoproteins (LDL) (p = .04); as well as somewhat lower levels of high-density lipoprotein (HDL) cholesterol (p = .04). Chi-squared analysis demonstrated a strong association between coronary artery disease and IDL apolipoprotein (apo) B (p = .006), coronary artery disease and IDL triglyceride (p = .032), and coronary artery disease and IDL apo B times IDL triglyceride (p = .006) when the top quintile of the population was compared with the bottom quintile for each of these variables. Stepwise logistic regression analysis resulted in rejection of an association between coronary artery disease and HDL cholesterol, plasma triglyceride, VLDL triglyceride, or LDL triglyceride. However, it did show that coronary artery disease was most strongly associated with smoking and that the second strongest association was with IDL.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
G Steiner; L Schwartz; S Shumak; M Poapst
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  75     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-10     Completed Date:  1987-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  124-30     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Apolipoproteins B / blood
Cholesterol / blood
Coronary Angiography
Coronary Disease / blood*
Humans
Lipoproteins / blood*
Lipoproteins, HDL / blood
Lipoproteins, IDL
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Male
Middle Aged
Risk
Smoking*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Apolipoproteins B; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, IDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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