| The association of homocysteine and coronary artery disease. | |
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MedLine Citation:
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PMID: 14677809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperhomocysteinemia has been associated with increased risk of atherosclerosis and myocardial infarction by a number of prospective case-control studies. A variety of genetic mutations, nutritional deficiencies, disease states, and drugs can elevate homocysteine concentrations. Treatment with folic acid with or without B-complex vitamins effectively lowers homocysteine levels. Whether therapy corresponds with decreased risk of coronary events is unknown, but may be promising. This article reviews the biochemistry of homocysteine metabolism, pathogeneisis, and etiology of hyperhomocysteinemia, along with its association with coronary artery disease, screening, and treatment. |
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Authors:
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Gregory M Gauthier; Jon G Keevil; Patrick E McBride |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical cardiology Volume: 26 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-17 Completed Date: 2004-04-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 563-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA. gm.gauthier@hosp.wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Artery Disease
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blood,
etiology* Homocysteine / metabolism* Humans Hyperhomocysteinemia / complications*, etiology, therapy* Risk Factors |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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