Document Detail


The association of homocysteine and coronary artery disease.
MedLine Citation:
PMID:  14677809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperhomocysteinemia has been associated with increased risk of atherosclerosis and myocardial infarction by a number of prospective case-control studies. A variety of genetic mutations, nutritional deficiencies, disease states, and drugs can elevate homocysteine concentrations. Treatment with folic acid with or without B-complex vitamins effectively lowers homocysteine levels. Whether therapy corresponds with decreased risk of coronary events is unknown, but may be promising. This article reviews the biochemistry of homocysteine metabolism, pathogeneisis, and etiology of hyperhomocysteinemia, along with its association with coronary artery disease, screening, and treatment.
Authors:
Gregory M Gauthier; Jon G Keevil; Patrick E McBride
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  26     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-17     Completed Date:  2004-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  563-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA. gm.gauthier@hosp.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Coronary Artery Disease / blood,  etiology*
Homocysteine / metabolism*
Humans
Hyperhomocysteinemia / complications*,  etiology,  therapy*
Risk Factors
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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