Document Detail

The association of hip circumference with incident hip fracture in a cohort of postmenopausal women: the Iowa Women's Health Study.
MedLine Citation:
PMID:  18940632     Owner:  NLM     Status:  MEDLINE    
PURPOSE: As the mean age of the U.S. population increases, the public health burden of osteoporotic fractures is expected to increase. This study prospectively examined the independent association of hip circumference with hip fracture.
METHODS: The prospective association of hip circumference and hip fracture was examined in a cohort of 30,652 postmenopausal women.
RESULTS: Compared with the lowest quintile, successive quintiles of hip circumference were associated with a reduced hazard (i.e., hazard ratio [HR]) of hip fracture over 18 years of follow-up (HRs = 1.00, 0.78, 0.74, 0.76, 0.69, p for trend = 0.0015) after adjusting for age. Controlling for waist, this association persisted (HRs = 1.00, 0.78, 0.73, 0.72, 0.54, p for trend = 0.0006). When additionally controlling for body mass index (BMI), we found that the association of hip fracture with hip circumference was attenuated to the null whereas the association with successive quintiles of BMI remained significant and inverse (HRs = 1.00, 0.55, 0.45, 0.40, 0.35, p for trend <0.0001).
CONCLUSIONS: Although hip circumference has a strong inverse association with risk of hip fracture, this association was not independent of BMI. These results suggest that, in the prediction of hip fracture risk, overall body size may be more important than body composition of the femoral-gluteal region.
Emily D Parker; Mark A Pereira; Beth Virnig; Aaron R Folsom
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of epidemiology     Volume:  18     ISSN:  1873-2585     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2008-11-26     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  836-41     Citation Subset:  IM    
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MeSH Terms
Body Mass Index*
Health Surveys
Hip / anatomy & histology*
Hip Fractures / etiology*
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
Waist-Hip Ratio
Grant Support
R01 CA039742/CA/NCI NIH HHS; R01 CA039742-24/CA/NCI NIH HHS; R01 CA39742/CA/NCI NIH HHS; T32 HL07779/HL/NHLBI NIH HHS

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