Document Detail


The association of growth differentiation factor-15 with left ventricular hypertrophy in hypertensive patients.
MedLine Citation:
PMID:  23071585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growth differentiation factor-15 (GDF-15) has been identified as an endogenous anti-hypertrophy effect. However, the association of plasma GDF-15 levels with left ventricular hypertrophy (LVH) in hypertension is poorly understood. We investigate the effect of plasma GDF-15 levels on left ventricular hypertrophy (LVH) in hypertension. We measured the plasma levels of GDF-15 in 299 untreated hypertensive patients which consisted of 99 with LVH and 200 without LVH using immunoradiometric assay. All subjects were examined by the ultrasonic cardiograph to determine Left ventricular (LV) internal diameters, septal thickness, and posterior wall thickness. The associations of GDF-15 with left ventricular mass index (LVMI), LV end-systolic and -diastolic diameters, LV wall thickness, and LV ejection fraction were evaluated. We found that plasma GDF-15 levels in hypertensive patients with LVH [median 1101, 25th-75th percentiles (879-1344) ng/L] were higher than that in hypertensive patients without LVH [median 516, 25th-75th percentiles (344-640) ng/L] (P<0.001). After adjustment for traditional covariates, plasma GDF-15 levels were independently related to LVMI (R(2) = 0.53; β = 0.624, P<0.001), LV interventricular septal thickness (R(2) = 0.23; β = 0.087, P<0.01) and LV posterior wall thickness (R(2) = 0.26; β = 0.103, P<0.05). Our cross-sectional data on a hospital-based sample indicate that plasma GDF-15 levels are associated with LVH in hypertensive patients.
Authors:
Hao Xue; Zhenhong Fu; Yundai Chen; Youhong Xing; Jie Liu; Hang Zhu; Xiao Zhou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-11
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-16     Completed Date:  2013-04-02     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e46534     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China. xuehao301@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Cross-Sectional Studies
Female
Growth Differentiation Factor 15 / blood*
Heart Ventricles / pathology
Humans
Hypertension / blood*,  complications,  ultrasonography
Hypertrophy, Left Ventricular / blood*,  etiology,  ultrasonography
Logistic Models
Male
Middle Aged
Multivariate Analysis
ROC Curve
Chemical
Reg. No./Substance:
0/GDF15 protein, human; 0/Growth Differentiation Factor 15
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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