Document Detail

The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population.
MedLine Citation:
PMID:  21151336     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients.
METHODS: Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients and 162 unaffected controls.
RESULTS: In the current study we describe a significant gender-specific association of GSTT1 and GSTM1 null genotypes with PEXG. The three null genotype combinations (i.e., T1M0, T0M1, and T0M0) were found at significantly higher frequencies in the PEXG patients as compared to the controls (χ(2)=21.82, p<0.001). This association was specifically related to the female patients (χ(2)=35.63, p<0.001); no such association was seen in the male patients (χ(2)=2.28, p>0.05).
CONCLUSIONS: The results suggest that there is a significant involvement of the GSTT1 and GSTM1 polymorphisms in female Pakistani patients having PEXG, which suggests a possible gender-specific impairment of detoxification in this group.
Muhammad Imran Khan; Shazia Micheal; Farah Akhtar; Waqar Ahmed; Bushra Ijaz; Asifa Ahmed; Raheel Qamar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-26
Journal Detail:
Title:  Molecular vision     Volume:  16     ISSN:  1090-0535     ISO Abbreviation:  Mol. Vis.     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-02-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9605351     Medline TA:  Mol Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2146-52     Citation Subset:  IM    
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
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MeSH Terms
Case-Control Studies
Chromosome Segregation / genetics
Exfoliation Syndrome / complications,  enzymology,  genetics*
Genetic Association Studies*
Genetic Predisposition to Disease*
Glaucoma / complications,  enzymology,  genetics*
Glutathione Transferase / genetics*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Sex Characteristics
Reg. No./Substance:
EC 2.5.1.-/glutathione S-transferase T1; EC Transferase; EC S-transferase M1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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