Document Detail


The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population.
MedLine Citation:
PMID:  21151336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients.
METHODS: Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients and 162 unaffected controls.
RESULTS: In the current study we describe a significant gender-specific association of GSTT1 and GSTM1 null genotypes with PEXG. The three null genotype combinations (i.e., T1M0, T0M1, and T0M0) were found at significantly higher frequencies in the PEXG patients as compared to the controls (χ(2)=21.82, p<0.001). This association was specifically related to the female patients (χ(2)=35.63, p<0.001); no such association was seen in the male patients (χ(2)=2.28, p>0.05).
CONCLUSIONS: The results suggest that there is a significant involvement of the GSTT1 and GSTM1 polymorphisms in female Pakistani patients having PEXG, which suggests a possible gender-specific impairment of detoxification in this group.
Authors:
Muhammad Imran Khan; Shazia Micheal; Farah Akhtar; Waqar Ahmed; Bushra Ijaz; Asifa Ahmed; Raheel Qamar
Related Documents :
20205066 - increased sympathetic activity assessed by spectral analysis of heart rate variability ...
20658196 - Increased proinflammatory cytokine production in adipose tissue of obese patients with ...
9493846 - Prognostic value of serial serum interleukin-6 level estimation in patients with lung c...
21089116 - Higher c-reactive protein predicts worse prognosis in acute heart failure only in nonin...
1971646 - Results of a clinical and pharmacokinetic study of ceftazidime in patients with postope...
24934256 - A neutrophil intrinsic impairment affecting rab27a and degranulation in cystic fibrosis...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-26
Journal Detail:
Title:  Molecular vision     Volume:  16     ISSN:  1090-0535     ISO Abbreviation:  Mol. Vis.     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-02-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9605351     Medline TA:  Mol Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2146-52     Citation Subset:  IM    
Affiliation:
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Chromosome Segregation / genetics
Exfoliation Syndrome / complications,  enzymology,  genetics*
Female
Genetic Association Studies*
Genetic Predisposition to Disease*
Glaucoma / complications,  enzymology,  genetics*
Glutathione Transferase / genetics*
Humans
Male
Pakistan
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Sex Characteristics
Chemical
Reg. No./Substance:
EC 2.5.1.-/glutathione S-transferase T1; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Morphological bases of suppressive and facilitative spatial summation in the striate cortex of the c...
Next Document:  Epithelial microfilament regulators show regional distribution in mouse conjunctiva.