Document Detail


The association of dyslipoproteinemia with symptoms and signs of peripheral arterial disease. The Lipid Research Clinics Program Prevalence Study.
MedLine Citation:
PMID:  3940676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intermittent claudication, leg pain during a graded exercise test (GXT), and resting systolic pressures in the upper and lower extremities were recorded as indicators of peripheral arterial disease at visit 2 of the Lipid Research Clinics (LRC) Prevalence Study. Systolic pressures of the upper and lower extremities were measured in a subsample of participants. We compared lipid levels of persons with and without claudication and with or without GXT-induced leg pain. We also compared lipid levels between groups with high and low arm:ankle systolic blood pressure ratios. Twenty-one (1.0%) men, 10 (1.0%) female nonusers and six (1.0%) female users of gonadal hormones had intermittent claudication determined by standardized questionnaire. Men with claudication had lower high-density lipoprotein (HDL)-cholesterol (35.6 vs 46.4 mg/dl), and their mean triglyceride level and cigarette consumption were higher and regular exercise less frequent. Men with type IIb dyslipoproteinemia were more likely to report claudication. One hundred sixty-nine (4.0%) men, 101 (3.8%) female nonusers, and 47 (4.1%) female users of hormones stopped the GXT because of leg pain. Mean HDL-cholesterol levels were lower for those with GXT-induced leg pain in all three sex-hormone usage groups (42.0 vs 46.9, p less than .001; 53.9 vs 59.4, p less than .001; 65.3 vs 67.2, p = NS) and mean low-density lipoprotein cholesterol levels were higher in those with leg pain on GXT in two of three groups (146.4 vs 146.2, p = NS; 155.7 vs 144.6, p less than .01; 144.4 vs 133.5, p less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P Pomrehn; B Duncan; L Weissfeld; R B Wallace; R Barnes; G Heiss; L G Ekelund; M H Criqui; N Johnson; L E Chambless
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  73     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-01-30     Completed Date:  1986-01-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I100-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Exercise Test
Extremities / blood supply*
Female
Gonadal Steroid Hormones / pharmacology
Humans
Hyperlipoproteinemias / complications*
Hypolipoproteinemias / complications*
Intermittent Claudication / blood
Male
Middle Aged
Pain / etiology
Physical Exertion
Vascular Diseases / etiology*
Grant Support
ID/Acronym/Agency:
N01-HV1-2156-L/HV/NHLBI NIH HHS; N01-HV1-2160-L/HV/NHLBI NIH HHS; N01-HV2-2914-L/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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