Document Detail


The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents.
MedLine Citation:
PMID:  19154947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Desaturase 9 (Delta 9), which converts saturated fatty acids (SFAs) into monounsaturated fatty acids, is an important component in leptin-mediated energy homeostasis in rodent models. Few human studies, however, have been performed regarding the clinical relevance of Delta 9, particularly whether Delta 9 is involved in the relationship between blood fatty acid profiles and insulin resistance-associated factors. The aim of the present study was to examine fatty acid data from 178 apparently healthy female adolescents and determine whether (a) Delta 9 has independent associations with adiposity, insulin resistance level, and fasting plasma polyunsaturated fatty acids (PUFAs); (b) Delta 9 is a predictor of fasting blood lipid profile; and (c) the associations between fasting plasma fatty acid component and insulin resistance level are independent of abdominal obesity level. Desaturase 9-16 (surrogate of Delta 9 as calculated by plasma ratio C16:1 n-7/C16:0) correlated with waist girth (r = .160, P < .05), homeostasis model assessment of insulin resistance (HOMA-IR) (r = .201, P < .01), plasma PUFAs (eg, C20:4 n-6 [r = -.269, P < .001], C22:6 n-3 [r = -.274, P < .001]). After adjustment for dietary SFAs, Delta 9-16 had stronger correlation with waist (r = .227, P < .01) and significant correlation with PUFAs, whereas it had a nonsignificant correlation with HOMA-IR. The same pattern was observed with Delta 9-18 (surrogate of Delta 9 as calculated by plasma ratio C18:1 n-9/C18:0). After adjustment for dietary SFAs, waist, and HOMA-IR, Delta 9-16 and Delta 9-18 were still positive predictors of triglyceride (both P < .001) and apolipoprotein B (Delta 9-18, P < .001; Delta 9-16, P = .052). After adjustment for waist, HOMA-IR only remained a positive determinant of medium-chain SFAs (C14:0, P < .001; C16:0, P < .05); but it emerged to be inversely related to C20:4 n-6 (P < 0.1). The positive and independent associations of medium-chain SFAs with insulin resistance level suggest their vital roles in diabetes pathogenesis, whereas certain PUFAs such as C20:4 n-6 appear to be protective. The observed associations of Delta 9 with adiposity and plasma lipid profile in these apparently healthy female adolescents support the concept derived from rodent models that Delta 9 activity is independently reflective of higher body mass index and higher circulatory triglyceride levels.
Authors:
Yuan E Zhou; Grace M Egeland; Sara J Meltzer; Stan Kubow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  58     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-66     Citation Subset:  IM    
Affiliation:
School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat
Adolescent
Blood Glucose / metabolism
Cross-Sectional Studies
Dietary Fats / blood
Fatty Acids / blood*
Fatty Acids, Unsaturated / blood*
Female
Homeostasis / physiology
Humans
Hyperlipidemias / metabolism*
Insulin Resistance*
Lipoproteins / blood
Stearoyl-CoA Desaturase / blood*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; EC 1.14.19.1/Stearoyl-CoA Desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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