Document Detail

The association of congenital hypothyroidism and congenital gastrointestinal anomalies in Down's syndrome infants.
MedLine Citation:
PMID:  9642639     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the prevalence of congenital hypothyroidism in infants with Down's syndrome and to verify whether there is an association with other congenital defects. METHODS: This is a prospective study of 112 Down patients, less than 1 year of age, who attended Songklanagarind Hospital from January 1991 to December 1996. Free T4 and TSH determinations were performed in all Down infants. Information on karyotype, sex, maternal age and other congenital anomalies was collected. RESULTS: Congenital hypothyroidism was detected in 17 patients (15.2%); 3 overt congenital hypothyroidism; 6 persistent compensated hypothyroidism; and 8 transient compensated hypothyroidism. Nine of the 20 patients (45%) with congenital gastrointestinal anomalies had congenital hypothyroidism, while 8 out of 92 patients (8.7%) without congenital gastrointestinal anomalies had congenital hypothyroidism. The odds ratio was 8.59 (95% confidence interval 2.4-31.6; p = 0.0001). CONCLUSION: Congenital hypothyroidism has a relatively high prevalence rate in Down infants and tends to occur in Down patients with gastrointestinal anomalies.
S Jaruratanasirikul; N Patarakijvanich; C Patanapisarnsak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  11     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-09-01     Completed Date:  1998-09-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-6     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University Hat-Yai, Thailand.
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MeSH Terms
Congenital Hypothyroidism*
Digestive System Abnormalities*
Down Syndrome / complications*,  pathology
Hypothyroidism / epidemiology*
Infant, Newborn
Prospective Studies
Thyroid Function Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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