Document Detail

The association of chronic endometritis with preterm birth.
MedLine Citation:
PMID:  17403412     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine whether chronic endometritis (CE) that is diagnosed by endometrial biopsy is associated with preterm birth at <37 weeks of gestation. STUDY DESIGN: Pathology reports for women aged 18-45 years who underwent clinically indicated endometrial biopsy between 1992 and 2002 were solicited from 3 participating clinical pathology laboratories. Reports were dichotomized into those with and those without CE by a standard definition. Results were linked to birth certificates at the Ohio Department of Health. Women who delivered singleton infants (1992-2002) within 3 years of biopsy were included. Biopsy specimens that were obtained from women with conditions that were associated with indicated preterm birth were excluded. Statistical analysis included logistic regression, Student's t-test, Fisher's exact test, and chi-square test, where appropriate. A probability value of <.05 was considered significant. RESULTS: The 1603 endometrial biopsy reports were identified and forwarded. The Ohio Department of Health linked birth certificate data to 193 reports, 157 of which met inclusion criteria and comprised the study group. Twenty-six of 157 women (16.6%) who were studied had CE. The odds of delivering at <37 weeks of gestation were not significantly higher for women with CE (odds ratio, 2.51; 95% CI, 0.86-7.29; P = .091). Infants who were born at <37 weeks of gestation were more likely to be black (P < .001); to have intrapartum fever, meconium, or fetal distress (P = .026) and to require assisted ventilation (P = .016). CONCLUSION: In our study group, women with CE were not more likely to deliver an infant at <37 weeks of gestation.
Eric J Knudtson; Cynthia Shellhaas; Julie A Stephens; Molly Senokozlieff; Huaide Ye; Jay D Iams
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  196     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-03     Completed Date:  2007-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337.e1-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, USA.
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MeSH Terms
Biopsy, Needle
Chronic Disease
Cohort Studies
Confidence Intervals
Endometritis / epidemiology*,  pathology*
Gestational Age
Infant, Newborn
Logistic Models
Middle Aged
Odds Ratio
Pregnancy Complications / diagnosis,  epidemiology*
Pregnancy Outcome
Pregnancy, High-Risk*
Premature Birth / epidemiology*
Retrospective Studies
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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