Document Detail

The association of bullous pemphigoid and malignant disease: a case control study.
MedLine Citation:
PMID:  2095174     Owner:  NLM     Status:  MEDLINE    
In a case control study, the incidence of malignant disease in 84 patients with bullous pemphigoid (BP) was compared with 168 controls. The rate of malignant disease (past, concurrent or during follow-up) in BP patients was 17.9% compared to 5.3% in the controls. A number of the malignancies occurring in the BP group may be of doubtful significance, being either temporally very remote or partially attributable to treatment. The rate of concurrent BP and malignancy (within 8 weeks) was 6.0% suggesting that there is probably a slight excess of malignancy in BP, but insufficient to warrant extensive investigation in pursuit of cancer. Comparison of the BP patients with and without cancer identified no clinical or immunopathological subgroups in whom investigations would be indicated. Three patients with both BP and malignancy were HLA-DR 13 positive, which may point to an immunogenetic predisposition to both diseases.
V A Venning; F Wojnarowska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  123     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-07-10     Completed Date:  1991-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  439-45     Citation Subset:  IM    
Department of Dermatology, Slade Hospital, Oxford.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
HLA Antigens / analysis
Middle Aged
Neoplasms / complications*
Pemphigoid, Bullous / complications*,  immunology
Reg. No./Substance:
0/HLA Antigens

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