Document Detail

The association between weight loss and increased longevity. A review of the evidence.
MedLine Citation:
PMID:  8363207     Owner:  NLM     Status:  MEDLINE    
Six published observational epidemiologic studies have reported evidence of reduced mortality rates in persons who have lost weight. In two studies, the reported protective effects of weight loss on mortality could not be justified by the data. In two other studies, weight loss was associated with both increased and decreased longevity in different subgroups. Only one study provided information on whether the weight loss was voluntary, but this study found similar effects of weight loss regardless of volition. These studies provided only limited information on the magnitude of weight loss associated with changes in longevity and no information on the types of methods used to achieve weight loss. Because of difficulties in studying long-term health outcomes related to obesity treatment, randomized, controlled trials are unlikely to provide a practical study design for this issue. Properly designed observational studies will probably provide the most useful information on the effects of voluntary weight loss on longevity.
D F Williamson; E R Pamuk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of internal medicine     Volume:  119     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-09-27     Completed Date:  1993-09-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  731-6     Citation Subset:  AIM; IM    
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
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MeSH Terms
Epidemiologic Methods
Great Britain
United States
Weight Loss / physiology*
Comment In:
Ann Intern Med. 1995 Dec 1;123(11):892   [PMID:  7486479 ]

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