| An association between successful vaccination against the bovine nodular worm, Oesophagostomum radiatum and induction of eosinophilia. | |
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MedLine Citation:
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PMID: 7806267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunization of 48 cattle with somatic antigen extracts of the nodular worm, Oesophagostomum radiatum, reduced faecal egg counts (FEC) by 51% and worm burden by 47%. The antibody titre of each animal was correlated to both worm burden (r = -0.40, P < 0.005) and FEC (r = -0.37, P < 0.01). The vaccinated cattle showed wide variation in their response to vaccination with worm burdens after challenge infection varying from 0 to 4060. Of these 48 vaccinated animals, eight developed sterile immunity (worm burden = 0, FEC = 0) whereas a further 10 had no protective response to immunization (worm burden > 1,000, FEC > 100). A comparison of these two sub-groups showed that the group with sterile immunity had a higher antibody titre (P < 0.05). In addition, the group with sterile immunity developed a blood eosinophilia between 21 and 29 days after challenge infection. Vaccinated, unprotected calves and control, unvaccinated calves did not develop eosinophilia. |
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Authors:
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I J East |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunology and cell biology Volume: 72 ISSN: 0818-9641 ISO Abbreviation: Immunol. Cell Biol. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-01-30 Completed Date: 1995-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706300 Medline TA: Immunol Cell Biol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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CSIRO Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, Queensland, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Helminth / immunology* Eosinophilia / etiology, immunology, veterinary* Male Oesophagostomiasis / complications, immunology, parasitology, therapy, veterinary* Oesophagostomum / immunology*, isolation & purification Parasite Egg Count / veterinary Vaccination / veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Helminth |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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