| The association between stillbirth in the first pregnancy and subsequent adverse perinatal outcomes. | |
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MedLine Citation:
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PMID: 19691947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to examine the association between first-pregnancy stillbirth and subsequent adverse perinatal outcomes. STUDY DESIGN: This cohort study examined the first 2 singleton deliveries at 20-44 weeks' gestation from 1991-2008 (n = 71,315) using birth certificate, hospitalization, and outpatient encounter files. Multivariable logistic regression models were used to assess the association. RESULTS: Stillbirth was observed in 5.3 of 1000 first deliveries. There was an increased risk of ischemic placental disease (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.2-2.1), fetal distress (OR, 2.8; 95% CI, 1.7-4.5), chorioamnionitis (OR, 2.3; 95% CI 1.5-4.3), extreme preterm birth (OR, 4.2; 95% CI, 1.8-9.9), and early neonatal mortality (OR, 8.3; 95% CI, 3.7-18.6) in pregnancies after stillbirth vs pregnancies after live birth. Interpregnancy intervals <2 and > or =4 years after stillbirth increased the risk of ischemic placental disease and spontaneous preterm birth. Risks varied by stillbirth subtype. CONCLUSION: A first-pregnancy stillbirth may increase adverse perinatal outcomes in subsequent pregnancy. |
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Authors:
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Darios Getahun; Jean M Lawrence; Michael J Fassett; Daniel Strickland; Corinna Koebnick; Wansu Chen; Steven J Jacobsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-18 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 201 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-30 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 378.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Research and Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA 91101, USA. Darios.T.Getahun@kp.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorioamnionitis / epidemiology Female Fetal Distress / epidemiology Gestational Age Humans Logistic Models Pregnancy Pregnancy Outcome* Stillbirth / epidemiology* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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