| The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. | |
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MedLine Citation:
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PMID: 18686203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The associations between a polymorphism of the serotonin transporter gene (5-HTTLPR), dental mercury exposure, and self-reported symptoms were evaluated among 157 male dentists and 84 female dental assistants. Self-reported symptoms and detailed work histories were obtained by computerized questionnaire. Spot urine samples were collected and analyzed for mercury concentrations to evaluate recent exposures, whereas a chronic mercury exposure index was created from the work histories. 5-HTTLPR polymorphism status was determined using a polymerase chain reaction (PCR)-based assay. Scores for current, recent, and chronic self-reported symptom groups were evaluated with respect to recent and chronic mercury exposure and 5-HTTLPR polymorphism status. Multiple regression analysis controlled for age, socioeconomic status, tobacco and alcohol use, self-reported health problems, and medications. Analyses were restricted to Caucasian subjects due to the highly skewed distribution of the 5-HTTLPR polymorphism. Separate evaluations were conducted for dentists and dental assistants. In contrast to previous reports, no consistent associations were found between either urinary mercury concentration or the chronic index of mercury exposure and any category of symptoms. However, both significant and consistent associations were observed between increased symptoms and the 5-HTTLPR polymorphism involving two copies of the short or "s" allele (full mutation), but not with the polymorphism involving only one copy (heterozygous), demonstrating a gene-dose relationship for symptom reporting. These findings suggest that within this restricted population increased symptoms of depression, anxiety, and memory are associated with the 5-HTTLPR polymorphism among both males and females. |
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Authors:
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Nicholas J Heyer; Diana Echeverria; Federico M Farin; James S Woods |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part A Volume: 71 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-09-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: England |
Other Details:
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Languages: eng Pagination: 1318-26 Citation Subset: IM |
Affiliation:
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Battelle Centers for Public Health Research and Evaluation, Seattle, Washington 98109-3598, USA. heyern@battelle.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anxiety
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genetics Cohort Studies Dental Amalgam / chemistry, toxicity* Dental Assistants Dentists Depression / genetics European Continental Ancestry Group Female Genetic Predisposition to Disease / genetics* Health Surveys Humans Male Memory Disorders / genetics Mercury / urine Mercury Poisoning, Nervous System / genetics* Occupational Diseases / genetics Occupational Exposure / adverse effects* Polymorphism, Single Nucleotide / genetics* Serotonin Plasma Membrane Transport Proteins / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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P30 ES007033-069006/ES/NIEHS NIH HHS; P30 ES007033-06S19006/ES/NIEHS NIH HHS; P30 ES007033-06S29006/ES/NIEHS NIH HHS; P30 ES007033-079006/ES/NIEHS NIH HHS; P30 ES007033-07S19006/ES/NIEHS NIH HHS; P30 ES007033-089006/ES/NIEHS NIH HHS; P30 ES007033-099006/ES/NIEHS NIH HHS; P30 ES007033-109006/ES/NIEHS NIH HHS; P42 ES004696-110002/ES/NIEHS NIH HHS; P42 ES004696-180002/ES/NIEHS NIH HHS; P42 ES004696-190002/ES/NIEHS NIH HHS; P42 ES004696-200002/ES/NIEHS NIH HHS; P42 ES004696-210002/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 7439-97-6/Mercury; 8049-85-2/Dental Amalgam |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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