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The association between salt intake and adult systolic blood pressure is modified by birth weight.
MedLine Citation:
PMID:  21068355     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Epidemiologic evidence suggests that prenatal growth influences adult blood pressure. Nutritional factors, including salt intake, also influence blood pressure. However, it is unknown whether prenatal growth modifies the association between salt intake and blood pressure in later life.
OBJECTIVE: Our aim was to examine whether the relation between salt intake and adult blood pressure is modified by birth weight.
DESIGN: We studied 1512 participants of the Helsinki Birth Cohort Study who were born between 1934 and 1944. Information on birth weight was abstracted from birth records, and preterm births were excluded. During a clinical study, at the mean age of 62 y, blood pressure, weight, and height were measured. Diet was assessed with a validated food-frequency questionnaire. The relation between salt intake and blood pressure was tested by a piecewise multivariate regression analysis with the best fitting breakpoints to birth weight and salt intake.
RESULTS: An inverse association was observed between birth weight and systolic blood pressure (SBP) (P = 0.02). No significant association between salt intake and SBP was observed in the whole study population. Of those whose birth weight was ≤3050 g, a 1-g higher daily salt intake was associated with a 2.48-mm Hg (95% CI: 0.40, 4.52 mm Hg) higher SBP (P = 0.017) until the saturation point of 10 g. Of those whose birth weight exceeded 3050 g, SBP was not significantly associated with salt intake. For diastolic blood pressure, no significant relations were observed.
CONCLUSION: Adult individuals with low birth weight may be particularly sensitive to the blood pressure-raising effect of salt.
Mia-Maria Perälä; Elena Moltchanova; Niina E Kaartinen; Satu Männistö; Eero Kajantie; Clive Osmond; David Jp Barker; Liisa M Valsta; Johan G Eriksson
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Publication Detail:
Type:  Journal Article     Date:  2010-11-10
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  93     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  AIM; IM    
Department of Lifestyle and Participation and of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
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