| The association between the renin-angiotensin-aldosterone system and arterial stiffness in young healthy subjects. | |
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MedLine Citation:
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PMID: 18194491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldosterone might affect arterial stiffening, in both the short- and long-term. We investigated a possible association between excess aldosterone, reflected by an increased aldosterone : renin ratio (ARR) and pulse wave velocity (PWV) in young healthy adults. In a single-centre study, 60 subjects were evaluated for lipid profile, glucose, hs-CRP, renin and aldosterone. PWV was performed as a simple non-invasive recording and computer analysis of the two artery sites pressure waveform using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia). The ARR was significantly, positively associated with PWV: r = 0.298, P = 0.02. ARR was not associated with anthropometric variables, blood pressure (BP), metabolic and inflammatory parameters. In conclusion, the ARR was significantly associated with PWV and may exhibit direct effects of aldosterone on the vascular wall, which are not related to changes in conventional cardiovascular risk factors. |
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Authors:
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Y Shapiro; M Boaz; Z Matas; A Fux; M Shargorodsky |
Publication Detail:
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Type: Journal Article Date: 2008-01-10 |
Journal Detail:
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Title: Clinical endocrinology Volume: 68 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-14 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 510-2 Citation Subset: IM |
Affiliation:
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Department of Medicine, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood* Arteries / physiology* Atherosclerosis / physiopathology Blood Flow Velocity Blood Pressure / physiology* Female Humans Male Middle Aged Renin / blood* Renin-Angiotensin System / physiology* |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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