| The association between metabolic syndrome and infarct size in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 20429699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In patients with the metabolic syndrome, the prevalence of cardiovascular disease, disease-related morbidity and mortality are reported to be significantly higher than in a population without the metabolic syndrome. We investigated the role of metabolic syndrome and related biomarkers as predictors of infarct size in patients with their first myocardial infarction. METHODS: This was a cross-sectional sub-study from the 3 months follow-up in the NORwegian Study of DIstrict treatment of ST-Elevation Myocardial Infarction (NORDISTEMI), including 152 consecutive patients, all initially treated with thrombolysis. Infarct size after 3 months was determined by late gadolinium enhanced magnetic resonance imaging, measuring ventricular infarct volume in absolute and relative terms. RESULTS: At 3 months, 33 patients (22%) were categorized as having metabolic syndrome. There was no significant difference in median infarct size between those presenting with and without the metabolic syndrome [relative infarct volume 9.0 (4.8, 15.1) % vs. 8.3 (2.9, 13.6)%, p = 0.34]. Adjusting for possible confounders did not alter the results essentially. Circulating levels of IL-18, CRP and PAI-I activity were significantly higher in patients with the metabolic syndrome while adiponectin concentrations were significantly lower (p < or = 0.01 for all). None of these variables were associated with myocardial infarct size. CONCLUSIONS: No association between the presence of metabolic syndrome and related biomarkers, and the size of the myocardial infarction was apparent in this study population. |
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Authors:
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Ellen Bøhmer; Ingebjørg Seljeflot; Harald Arnesen; Pavel Hoffmann; Michael Abdelnoor; Sigrun Halvorsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 70 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-07-13 Revised Date: 2010-12-02 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: England |
Other Details:
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Languages: eng Pagination: 287-93 Citation Subset: IM |
Affiliation:
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Oslo University Hospital, Ulleval, Department of Cardiology, Oslo, Norway. ellen.bohmer@sykehuset-innlandet.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Biological Markers / blood Cross-Sectional Studies Female Humans Interleukin-18 / blood Magnetic Resonance Imaging Male Metabolic Syndrome X / blood, complications*, epidemiology Middle Aged Myocardial Infarction / blood, complications*, pathology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers; 0/Interleukin-18 |
| Comments/Corrections | |
Comment In:
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Scand J Clin Lab Invest. 2010 Dec;70(8):592
[PMID:
20942740
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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