Document Detail

The association between metabolic syndrome and infarct size in patients with acute myocardial infarction.
MedLine Citation:
PMID:  20429699     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In patients with the metabolic syndrome, the prevalence of cardiovascular disease, disease-related morbidity and mortality are reported to be significantly higher than in a population without the metabolic syndrome. We investigated the role of metabolic syndrome and related biomarkers as predictors of infarct size in patients with their first myocardial infarction.
METHODS: This was a cross-sectional sub-study from the 3 months follow-up in the NORwegian Study of DIstrict treatment of ST-Elevation Myocardial Infarction (NORDISTEMI), including 152 consecutive patients, all initially treated with thrombolysis. Infarct size after 3 months was determined by late gadolinium enhanced magnetic resonance imaging, measuring ventricular infarct volume in absolute and relative terms.
RESULTS: At 3 months, 33 patients (22%) were categorized as having metabolic syndrome. There was no significant difference in median infarct size between those presenting with and without the metabolic syndrome [relative infarct volume 9.0 (4.8, 15.1) % vs. 8.3 (2.9, 13.6)%, p = 0.34]. Adjusting for possible confounders did not alter the results essentially. Circulating levels of IL-18, CRP and PAI-I activity were significantly higher in patients with the metabolic syndrome while adiponectin concentrations were significantly lower (p < or = 0.01 for all). None of these variables were associated with myocardial infarct size.
CONCLUSIONS: No association between the presence of metabolic syndrome and related biomarkers, and the size of the myocardial infarction was apparent in this study population.
Ellen Bøhmer; Ingebjørg Seljeflot; Harald Arnesen; Pavel Hoffmann; Michael Abdelnoor; Sigrun Halvorsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  70     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-07-13     Revised Date:  2010-12-02    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
Oslo University Hospital, Ulleval, Department of Cardiology, Oslo, Norway.
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MeSH Terms
Adiponectin / blood
Biological Markers / blood
Cross-Sectional Studies
Interleukin-18 / blood
Magnetic Resonance Imaging
Metabolic Syndrome X / blood,  complications*,  epidemiology
Middle Aged
Myocardial Infarction / blood,  complications*,  pathology
Severity of Illness Index
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Interleukin-18
Comment In:
Scand J Clin Lab Invest. 2010 Dec;70(8):592   [PMID:  20942740 ]

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