Document Detail

The association between maternal cocaine use during pregnancy and physiological regulation in 4- to 8-week-old infants: an examination of possible mediators and moderators.
MedLine Citation:
PMID:  15788714     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between maternal cocaine use during pregnancy and physiological measures of regulation, which included heart rate (HR) and respiratory sinus arrhythmia (RSA).
METHODS: Potential mediators and moderators of this association were explored. Participants were 141 mother-infant dyads (77 cocaine exposed and 64 nonexposed) recruited at birth. Average infant HR and RSA was assessed at 4-8 weeks of age during a 15 minute period of sleep.
RESULTS: Results indicated a dose-dependent effect of prenatal exposure to cocaine on RSA. There was no evidence that fetal growth or other prenatal exposure to substances mediated this association or that fetal growth or maternal age moderated this association. Regression analyses also indicated that birth weight (BW), but not birthlength (BL), head circumference (HC) or other substance use, mediated the association between prenatal exposure to cocaine and heart rate.
CONCLUSIONS: These results suggest that cocaine exposure is associated with physiological regulation at 4-8 weeks of age and highlight the importance of considering level of exposure when assessing infant outcomes.
Pamela Schuetze; Rina D Eiden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-03-23
Journal Detail:
Title:  Journal of pediatric psychology     Volume:  31     ISSN:  0146-8693     ISO Abbreviation:  J Pediatr Psychol     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-03-23     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7801773     Medline TA:  J Pediatr Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-26     Citation Subset:  IM    
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MeSH Terms
Cocaine-Related Disorders / epidemiology*
Developmental Disabilities / epidemiology*
Fetal Diseases / epidemiology*
Heart Rate, Fetal / physiology*
Infant, Newborn
Pregnancy Complications / epidemiology*
Prenatal Exposure Delayed Effects
Respiration Disorders / epidemiology*
Grant Support
1R01DA013190-01A2/DA/NIDA NIH HHS; R01 DA013190/DA/NIDA NIH HHS; R01 DA013190-01A2/DA/NIDA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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