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The association between maternal blood pressures and offspring size at birth in Southeast Asian women.
MedLine Citation:
PMID:  25444649     Owner:  NLM     Status:  Publisher    
BackgroundMaternal blood pressures in pregnancy is an important determinant of offspring size at birth. However, the relationship between maternal blood pressures and offspring¿s size at birth is not consistent and may vary between ethnic groups. We examined the relationship between maternal peripheral and central blood pressures and offspring size at birth in an Asian multi-ethnic cohort, and effect modifications by maternal ethnicity and obesity.MethodsWe used data from 713 participants in the Growing Up in Singapore Towards Healthy Outcomes study consisting of pregnant Chinese, Malay and Indian women recruited from two tertiary hospitals between 2009 to 2010. Peripheral systolic and diastolic blood pressures (SBP and DBP), and central SBP and pulse pressure (PP) were measured around 27 weeks of gestation. Biometric parameters at birth were collected from medical records.ResultsAfter adjusting for maternal and fetal covariates, each 1-SD increase (10.0 mmHg) in central SBP was inversely associated with birth weight (¿40.52 g; 95% confidence interval (CI) -70.66 to ¿10.37), birth length (¿0.19 cm; ¿0.36 to ¿0.03), head circumference (¿0.12 cm; ¿0.23 to ¿0.02) and placental weight (¿11.16 g; ¿20.85 to ¿1.47). A one-SD (11.1 mmHg) increase in peripheral SBP was also associated with lower birth weight (¿35.56 g; ¿66.57 to ¿4.54). The inverse relations between other blood pressure measures and offspring size at birth were observed but not statistically significant. Higher peripheral SBP and DBP and central SBP were associated with increased odds of low birth weight (defined as weight <2500 g) and small for gestational age (defined as <10th percentile for gestational age adjusted birth weight). Maternal adiposity modified these associations, with stronger inverse associations in normal weight women. No significant interactions were found with ethnicity.ConclusionsHigher second-trimester peripheral and central systolic pressures were associated with smaller offspring size at birth, particularly in normal weight women. Findings from this study reinforces the clinical relevance of antenatal blood pressure monitoring.
Wai-Yee Lim; Yung-Seng Lee; Chuen-Seng Tan; Kenneth Kwek; Yap-Seng Chong; Peter D Gluckman; Keith M Godfrey; Seang-Mei Saw; An Pan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-2
Journal Detail:
Title:  BMC pregnancy and childbirth     Volume:  14     ISSN:  1471-2393     ISO Abbreviation:  BMC Pregnancy Childbirth     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  100967799     Medline TA:  BMC Pregnancy Childbirth     Country:  -    
Other Details:
Languages:  ENG     Pagination:  403     Citation Subset:  -    
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