| The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes. | |
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MedLine Citation:
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PMID: 14754776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was conducted to determine whether or not depression is associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes. METHOD: Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and interleukin-6 (IL-6) and the serum level of C-reactive protein were measured in 481 patients 2 months after hospitalization for acute coronary syndromes. Diagnosis of major depression was based on the Structured Clinical Interview for DSM-IV. RESULTS: Depressed patients showed significantly higher sICAM-1 levels, a difference that remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Although there was no significant association between depression and IL-6, there was an interaction between depression and statin therapy for levels of C-reactive protein. Depressed patients not taking statins had markedly higher C-reactive protein levels than did nondepressed patients. There was no relationship with depression in those receiving statins. CONCLUSIONS: These results suggest chronic endothelial activation among depressed patients after acute coronary syndromes. Further research is needed to determine whether or not higher levels of sICAM-1 may identify a subgroup of depressed patients at particularly high risk for cardiac events among patients with established coronary artery disease or among those without previous coronary artery disease. |
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Authors:
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François Lespérance; Nancy Frasure-Smith; Pierre Théroux; Michael Irwin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of psychiatry Volume: 161 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-02 Completed Date: 2004-04-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 271-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, Centre Hospitalier de l'Université de Montréal, Quebec, Canada. francois.lesperance@umontreal.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Body Mass Index C-Reactive Protein / metabolism* Comorbidity Coronary Disease / blood*, epidemiology Depressive Disorder, Major / blood*, epidemiology Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / blood Intercellular Adhesion Molecule-1 / blood* Interleukin-6 / blood* Male Middle Aged Obesity / epidemiology Prevalence |
| Grant Support | |
ID/Acronym/Agency:
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MH-55253/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Interleukin-6; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Am J Psychiatry. 2005 Jan;162(1):195; author reply 195
[PMID:
15625228
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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