Document Detail

Is the association between low birth weight and asthma independent of genetic and shared environmental factors?
MedLine Citation:
PMID:  19357326     Owner:  NLM     Status:  MEDLINE    
Epidemiologic evidence linking birth weight and asthma is inconsistent. The authors examined the association between birth weight and asthma during childhood and adult life in twins. Using prospectively collected data on 21,588 like-sexed Swedish twins of known zygosity born in 1928-1952, they first conducted a cohort study to examine the risk of asthma in relation to birth weight. Next, they conducted nested co-twin control analyses among 643 dizygotic and 365 monozygotic twin pairs discordant for asthma to ascertain whether the association between birth weight and asthma could be confounded by genetic and shared environmental exposures. In the cohort analysis, birth weight of <2,500 g was associated with significantly greater risk of asthma independent of perinatal characteristics and within-twin-pair correlations. In the co-twin control analyses, birth weight of <2,500 g was significantly related to increased risk of asthma among monozygotic twins (relative risk for 2,000 g vs. 2,500 g = 1.58, 95% confidence interval: 1.06, 2.38). A negative association between birth weight and asthma, albeit not statistically significant, was also found among dizygotic twins. In conclusion, there is a negative association between birth weight and asthma in twins that is unlikely to be confounded by genetic or shared environmental factors.
Eduardo Villamor; Anastasia Iliadou; Sven Cnattingius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2009-04-08
Journal Detail:
Title:  American journal of epidemiology     Volume:  169     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1337-43     Citation Subset:  IM    
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
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MeSH Terms
Asthma / epidemiology,  genetics*
Case-Control Studies
Child, Preschool
Diseases in Twins / epidemiology,  genetics*
Gestational Age
Infant, Low Birth Weight*
Infant, Newborn
Interviews as Topic
Prospective Studies
Regression Analysis
Risk Factors
Sweden / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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