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The association between low 50-g glucose challenge test result and fetal growth restriction.
MedLine Citation:
PMID:  23350735     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract OBJECTIVE: To determine whether a low GCT result is predictive of low birthweight and to identify the lower GCT threshold for prediction of fetal growth restriction. METHODS: A retrospective cohort study of 12,899 women who underwent a GCT (24 to 28 weeks). Women with a low GCT result (<10(th) percentile (70 mg/dL) were compared to women with normal GCT result (70-140 mg/dL). ROC analysis was used to determine the optimal lower GCT threshold for the prediction of growth restriction. RESULTS: Women in the low-GCT had significant lower rates of cesarean delivery (18.7% vs. 22.5%), shoulder dystocia (0.0% vs. 0.3%), mean birthweight (3096±576 vs. 3163±545) and birthweight percentile (49.1±27.0 vs. 53.1±26.7), and significant higher rates of birthweight< 2500g (11.3% vs. 8.5%), below the 10(th) percentile (8.3% vs. 6.5%) and 3(rd) percentile (2.3% vs. 1.4%). Low GCT was independently associated with an increased risk for birthweight<2500g (OR=1.6, 1.2-2.0), birthweight <10(th) percentile (OR=1.3, 1.1-1.6), birthweight <3(rd) percentile (OR=1.7, 1.2-2.5), and neonatal hypoglycemia (OR=1.4, 1.02-2.0). The optimal GCT threshold for the prediction of birthweight <10(th) percentile was 88.5 mg/dL (sensitivity 48.5%, specificity 58.1%). CONCLUSION: Low GCT result is independently associated with low birthweight and can be used in combination with additional factors for the prediction of fetal growth restriction.
Authors:
Nir Melamed; Liran Hiersch; Yoav Peled; Moshe Hod; Arnon Wiznitzer; Yariv Yogev
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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